The significance of serum SLC7A11 levels in the occurrence of vascular calcification in maintenance peritoneal dialysis patients.

IF 2.4 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephrology Pub Date : 2024-10-01 Epub Date: 2024-06-12 DOI:10.1111/nep.14334

Jing Wu, Junling Zhang, Qiong Tang, Huixian Zhu, Yan Chen, Hua Xiong, Hongwei Jiang

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引用次数: 0

Abstract

Aim: This research aimed to explore the serum levels of solute carrier family 7 member 11 (SLC7A11) in patients with maintenance peritoneal dialysis (MPD) and its correlation with vascular calcification (VC) and clinical results.

Methods: This present prospective observational cohort study enrolled 189 patients with MPD who were undergoing regular peritoneal dialysis for over 3 months in our hospital from February 2020 to July 2022. The abdominal aortic calcification score was used to assess the VC condition of MPD patients. The serum SLC7A11, interleukin (IL)-6, IL-1β and C-reactive protein levels were measured by enzyme-linked immunosorbent assay (ELISA). Demographic and clinical statistics were collected. All patients were followed up for 1 year and the overall survival time (OS) of all patients were recorded. All data used SPSS 18.0 for statistical analyses.

Results: Patients with moderate/severe calcification in MPD had a longer duration of dialysis, higher serum levels of phosphate (P) and calcium (Ca) and lower serum levels of SLC7A11. Spearman's analysis revealed a negative correlation between serum SLC7A11 levels and the levels of P, Ca and IL-1β. Additionally, we observed an association between serum SLC7A11 levels and clinical prognosis as well as the extent of VC in MPD patients. Multivariate logistic regression analysis indicated that dialysis duration, SLC7A11, and P were risk factors for VC in MPD patients.

Conclusion: The serum SLC7A11 levels decreased remarkably in MPD patients with moderate/severe calcification. This study may provide new targets and comprehensive approach to cardiovascular protection in patients with chronic kidney disease.

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维持性腹膜透析患者血清 SLC7A11 水平在血管钙化发生中的意义。

目的：本研究旨在探讨维持性腹膜透析（MPD）患者血清中溶质运载家族7成员11（SLC7A11）的水平及其与血管钙化（VC）和临床结果的相关性：本前瞻性观察队列研究纳入了2020年2月至2022年7月在我院接受定期腹膜透析3个月以上的189例MPD患者。腹主动脉钙化评分用于评估 MPD 患者的 VC 状况。采用酶联免疫吸附试验（ELISA）检测血清SLC7A11、白细胞介素（IL）-6、IL-1β和C反应蛋白水平。收集了人口统计学和临床统计数据。对所有患者进行为期一年的随访，并记录所有患者的总生存时间（OS）。所有数据均使用 SPSS 18.0 进行统计分析：MPD中度/重度钙化患者的透析时间较长，血清中磷酸盐（P）和钙（Ca）水平较高，血清中SLC7A11水平较低。斯皮尔曼分析显示，血清 SLC7A11 水平与磷酸盐、钙和 IL-1β 水平呈负相关。此外，我们还观察到血清 SLC7A11 水平与骨髓增生性疾病患者的临床预后以及 VC 的程度有关。多变量逻辑回归分析表明，透析时间、SLC7A11和P是骨髓增生性疾病患者发生VC的危险因素：结论：中度/重度钙化的骨髓增生性疾病患者血清 SLC7A11 水平明显下降。结论：中度/重度钙化的骨髓增生性疾病患者血清 SLC7A11 水平显著下降，该研究可为慢性肾脏病患者的心血管保护提供新的目标和综合方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephrology 医学-泌尿学与肾脏学

CiteScore

4.50

自引率

4.00%

发文量

128

审稿时长

4-8 weeks

期刊介绍： Nephrology is published eight times per year by the Asian Pacific Society of Nephrology. It has a special emphasis on the needs of Clinical Nephrologists and those in developing countries. The journal publishes reviews and papers of international interest describing original research concerned with clinical and experimental aspects of nephrology.