Applications of intelligent technology in the evaluation of mutagenicity

IF 2.3 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Mutation research. Genetic toxicology and environmental mutagenesis Pub Date : 2024-06-04 DOI:10.1016/j.mrgentox.2024.503785

Jia Li , Wenli Xu , Wenchao Zhang , Dingjin Liu , Shuyang Jiang , Guohua Liu , Yong Wang , Haoran Sun , Wenping Xu , Biao Jiang , Jianhua Yao

引用次数: 0

Abstract

Bioassays are widely used in assessment of mutagenicity. Alternative methods have also been developed, including “intelligent evaluation”, which depends on the quality of data, strategies, and techniques. CISOC-PSMT is an Ames test prediction system. The strategies and techniques for intelligent evaluation and four applications of CISOC-PSMT are presented; roles in pesticide management, environmental protection, drug discovery, and safety management of chemicals are introduced.

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智能技术在诱变性评估中的应用

生物测定被广泛应用于诱变性评估。人们还开发了其他方法，包括 "智能评估"，这取决于数据、策略和技术的质量。CISOC-PSMT 是一个埃姆斯试验预测系统。介绍了智能评估的策略和技术以及 CISOC-PSMT 的四种应用；介绍了其在农药管理、环境保护、药物发现和化学品安全管理方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mutation research. Genetic toxicology and environmental mutagenesis 生物-毒理学

CiteScore

3.80

自引率

5.30%

发文量

审稿时长

105 days

期刊介绍： Mutation Research - Genetic Toxicology and Environmental Mutagenesis (MRGTEM) publishes papers advancing knowledge in the field of genetic toxicology. Papers are welcomed in the following areas: New developments in genotoxicity testing of chemical agents (e.g. improvements in methodology of assay systems and interpretation of results). Alternatives to and refinement of the use of animals in genotoxicity testing. Nano-genotoxicology, the study of genotoxicity hazards and risks related to novel man-made nanomaterials. Studies of epigenetic changes in relation to genotoxic effects. The use of structure-activity relationships in predicting genotoxic effects. The isolation and chemical characterization of novel environmental mutagens. The measurement of genotoxic effects in human populations, when accompanied by quantitative measurements of environmental or occupational exposures. The application of novel technologies for assessing the hazard and risks associated with genotoxic substances (e.g. OMICS or other high-throughput approaches to genotoxicity testing). MRGTEM is now accepting submissions for a new section of the journal: Current Topics in Genotoxicity Testing, that will be dedicated to the discussion of current issues relating to design, interpretation and strategic use of genotoxicity tests. This section is envisaged to include discussions relating to the development of new international testing guidelines, but also to wider topics in the field. The evaluation of contrasting or opposing viewpoints is welcomed as long as the presentation is in accordance with the journal''s aims, scope, and policies.