Clinicopathological Impact of FOXM1 and MMP-9 Immunohistochemical Expression in Different Grades of Intracranial Meningioma.

IF 1.3 4区 医学 Q3 ANATOMY & MORPHOLOGY
Hanaa M Ibrahim, Aziza E Abdelrahman, Amira Elwan, Shimaa A Gharieb, Mohammed Refaat, Wael Elmesallamy, Amira A Salem
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引用次数: 0

Abstract

Objectives: To find predictive biomarkers for recurrence and progression of meningioma.

Background: Despite great advances in meningioma treatment, the prognosis remained unfavorable due to the high recurrence rate.

Methods: In this study, we evaluated the immunohistochemical expression of FOXM1, MMP-9, and Ki67 in 50 cases of intracranial meningioma to detect its potential role in meningioma progression, recurrence, and patients' survival.

Results: Strong FOXM1 expression was detected in 20% of the cases and was significantly associated with meningioma grade ( P = 0.002) and peritumoral brain edema (PTBE; P <0.001). Strong MMP-9 expression was noted in 32% of the cases and was significantly associated with meningioma grade and PTBE ( P <0.001, P <0.001, respectively). High Ki67 was noted in 50% and significantly associated with tumor grade and PTBE ( P <0.001, P = 0.002, respectively). The follow-up period revealed that meningiomas with strong FOXM1, strong MMP-9, and high Ki67 expression were associated with tumor recurrence, shorter OS, and recurrence-free survival. Furthermore, up-regulation of FOXM1 and MMP-9 expression had a significant relation with poor clinical response to the therapy ( P = 0.010, P = 0. 001, respectively). However, high Ki67 cases were more sensitive to clinical therapy ( P = 0.005).

Conclusion: Strong FOXM1, strong MMP-9, and high Ki67 in meningiomas indicate highly aggressive tumors with a shortened survival rate, dismal outcome, and high risk of recurrence after the standard protocol of therapy.

不同分级颅内脑膜瘤中 FOXM1 和 MMP-9 免疫组化表达的临床病理影响
目的:寻找脑膜瘤复发和进展的预测性生物标志物:寻找脑膜瘤复发和进展的预测性生物标志物:背景:尽管脑膜瘤的治疗取得了巨大进步,但由于复发率高,预后仍不乐观:本研究评估了50例颅内脑膜瘤中FOXM1、MMP-9和Ki67的免疫组化表达,以检测其在脑膜瘤进展、复发和患者生存中的潜在作用:结果:20%的病例检测到 FOXM1 强表达,且与脑膜瘤分级(P= 0.002)和瘤周脑水肿(PTBE;PConclusion)显著相关:脑膜瘤中FOXM1强表达、MMP-9强表达和Ki67高表达表明肿瘤具有高度侵袭性,在标准方案治疗后生存率缩短、预后不佳且复发风险高。
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来源期刊
Applied Immunohistochemistry & Molecular Morphology
Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY
CiteScore
3.20
自引率
0.00%
发文量
153
期刊介绍: ​Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology​.
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