The Role and Treatment Strategies of Ammonia-Related Metabolism in Tumor Microenvironment.

IF 3.8 4区 医学 Q2 GENETICS & HEREDITY
Qizhen Ye, Dan Li, Yi Zou, Ying Yuan
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引用次数: 0

Abstract

Tumor cells achieve their adaptability through various metabolic reprogramming processes. Among them, ammonia, as a traditional metabolic waste, plays an increasingly important role in the tumor microenvironment along with its associated metabolites. Other cells in the microenvironment can also reshape the immune status of the microenvironment by regulating ammonia-related metabolism, and targeting this metabolic aspect has emerged as a potential strategy for tumor treatment. In this study, we have systematically reviewed the source and destination of ammonia in tumor cells, as well as the links between ammonia and other biological processes. We have also analyzed the ammonia-related metabolic regulation of other cells (including T cells, macrophages, dendritic cells, natural killer cells, myeloid-derived suppressor cells, and stromal cells) in the tumor microenvironment, and summarized the tumor treatment methods that target this metabolism. Through ammonia-related metabolic reprogramming, tumor cells obtain the energy they need for rapid growth and proliferation. Multiple immune cells and stromal cells in the microenvironment also interact with each other through this metabolic regulation, ultimately leading to immune suppression. Despite the heterogeneity of tumors and the complexity of cellular functions, further research into therapeutic interventions targeting ammonia-related metabolism is warranted. This review has focused on the role and regulation of ammonia-related metabolism in tumor cells and other cells in the microenvironment, and highlighted the efficacy and prospects of targeted ammonia-related metabolism therapy.

氨相关代谢在肿瘤微环境中的作用和治疗策略
肿瘤细胞通过各种代谢重编程过程实现其适应性。其中,氨作为一种传统的代谢废物,与相关代谢产物一起在肿瘤微环境中发挥着越来越重要的作用。微环境中的其他细胞也可通过调节氨相关代谢重塑微环境的免疫状态,针对这一代谢环节的研究已成为治疗肿瘤的潜在策略。在本研究中,我们系统回顾了肿瘤细胞中氨的来源和去向,以及氨与其他生物过程之间的联系。我们还分析了肿瘤微环境中其他细胞(包括 T 细胞、巨噬细胞、树突状细胞、自然杀伤细胞、髓源抑制细胞和基质细胞)与氨相关的代谢调控,并总结了针对这种代谢的肿瘤治疗方法。通过与氨相关的代谢重编程,肿瘤细胞获得了快速生长和增殖所需的能量。微环境中的多种免疫细胞和基质细胞也通过这种代谢调节相互作用,最终导致免疫抑制。尽管肿瘤具有异质性和细胞功能的复杂性,但仍有必要进一步研究针对氨相关代谢的治疗干预措施。本综述重点探讨了氨相关代谢在肿瘤细胞和微环境中其他细胞中的作用和调控,并强调了氨相关代谢靶向治疗的疗效和前景。
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来源期刊
Current gene therapy
Current gene therapy 医学-遗传学
CiteScore
6.70
自引率
2.80%
发文量
46
期刊介绍: Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.
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