Fueling the success of transplantation through nutrition: recent insights into nutritional interventions, their interplay with gut microbiota and cellular mechanisms.

IF 1.8 4区 医学 Q3 TRANSPLANTATION
Felix C Koehler, Martin R Späth, Anna M Meyer, Roman-Ulrich Müller
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引用次数: 0

Abstract

Purpose of review: The role of nutrition in organ health including solid organ transplantation is broadly accepted, but robust data on nutritional regimens remains scarce calling for further investigation of specific dietary approaches at the different stages of organ transplantation. This review gives an update on the latest insights into nutritional interventions highlighting the potential of specific dietary regimens prior to transplantation aiming for organ protection and the interplay between dietary intake and gut microbiota.

Recent findings: Nutrition holds the potential to optimize patients' health prior to and after surgery, it may enhance patients' ability to cope with the procedure-associated stress and it may accelerate their recovery from surgery. Nutrition helps to reduce morbidity and mortality in addition to preserve graft function. In the case of living organ donation, dietary preconditioning strategies promise novel approaches to limit ischemic organ damage during transplantation and to identify the underlying molecular mechanisms of diet-induced organ protection. Functioning gut microbiota are required to limit systemic inflammation and to generate protective metabolites such as short-chain fatty acids or hydrogen sulfide.

Summary: Nutritional intervention is a promising therapeutic concept including the pre- and rehabilitation stage in order to improve the recipients' outcome after solid organ transplantation.

通过营养促进移植成功:对营养干预、其与肠道微生物群和细胞机制的相互作用的最新见解。
综述目的:营养在器官健康(包括实体器官移植)中的作用已被广泛接受,但有关营养方案的可靠数据仍然很少,因此需要进一步研究器官移植不同阶段的特定饮食方法。本综述介绍了营养干预的最新进展,强调了移植前特定膳食方案在器官保护方面的潜力,以及膳食摄入与肠道微生物群之间的相互作用:营养具有优化患者术前术后健康的潜力,可增强患者应对手术相关压力的能力,并可加快患者术后恢复。营养有助于降低发病率和死亡率,并能保持移植物的功能。在活体器官捐献的情况下,饮食预处理策略有望成为限制移植过程中缺血性器官损伤的新方法,并确定饮食诱导器官保护的潜在分子机制。小结:营养干预是一个很有前景的治疗概念,包括前期和康复阶段,以改善实体器官移植后受者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
4.50%
发文量
124
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
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