Breaking up the CD8+ T cell: Treg pas de deux

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-06-10 DOI:10.1016/j.ccell.2024.05.016

Chenyu Zhang, Alissa Bockman, Michel DuPage

引用次数: 0

Abstract

Checkpoint blockade immunotherapies, such as anti-programmed death-1 (PD-1), unleash anti-tumor CD8⁺ T cell responses but may also induce immunosuppressive regulatory T cells (Tregs). In this issue of Cancer Cell, Geels et al. uncover that anti-PD-1 leads to Treg expansion via interleukin-2 (IL-2)-producing CD8⁺ T cells. Combining anti-PD-1 with anti-ICOSL interrupts this crosstalk, thereby enhancing tumor control.

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分解 CD8+ T 细胞：Treg双人舞

检查点阻断免疫疗法，如抗程序性死亡-1（PD-1），能释放抗肿瘤 CD8+ T 细胞反应，但也可能诱导免疫抑制调节性 T 细胞（Tregs）。在本期《癌细胞》（Cancer Cell）杂志上，Geels 等人发现抗 PD-1 可通过产生白细胞介素-2（IL-2）的 CD8+ T 细胞导致 Treg 扩增。将抗-PD-1与抗-ICOSL结合可中断这种串扰，从而增强对肿瘤的控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.