Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton
IF 48.8
1区 医学
Q1 CELL BIOLOGY
引用次数: 0
Abstract
Cancer immunotherapy is a pillar of clinical oncology but only achieves long-term remissions in a minority of cases. In this issue, van Elsas et al. show that effective immunotherapy requires a series of processes orchestrated by CD8+ T cells that result in the recruitment and local activation of M1-like macrophages.
牵手成功的免疫疗法：CD8+ T 细胞和 M1 样巨噬细胞互换指挥棒
癌症免疫疗法是临床肿瘤学的支柱，但只有少数病例能实现长期缓解。在本期杂志中，van Elsas 等人的研究表明，有效的免疫疗法需要一系列由 CD8+ T 细胞协调的过程，这些过程会导致 M1 样巨噬细胞的招募和局部激活。
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来源期刊
Cancer Cell
医学-肿瘤学
CiteScore
55.20
自引率
1.20%
发文量
179
审稿时长
4-8 weeks
期刊介绍：
Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows:
Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers.
Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice.
Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers.
Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies.
Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.
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