Finding the sweet spot: Targeting RAS in tumors while sparing normal tissue

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-06-10 DOI:10.1016/j.ccell.2024.05.020

Naiara Perurena, Karen Cichowski

引用次数: 0

Abstract

The development of mutant-selective KRAS inhibitors represents a major therapeutic advance; however, patients can develop resistance through feedback mechanisms and genetic alterations in the RAS pathway. Three publications in Nature and Cancer Discovery describe a promising RAS(ON) multi-selective inhibitor that simultaneously targets oncogenic RAS and multiple potential resistance mechanisms while sparing normal tissue.

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寻找甜蜜点：靶向肿瘤中的 RAS，同时保护正常组织

突变选择性 KRAS 抑制剂的开发是治疗上的一大进步；然而，患者可能会通过 RAS 通路中的反馈机制和基因改变产生耐药性。自然》（Nature）和《癌症发现》（Cancer Discovery）杂志上发表的三篇论文介绍了一种很有前景的 RAS(ON) 多选择抑制剂，它能同时针对致癌 RAS 和多种潜在的耐药机制，同时保护正常组织。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.