Intraoral Salivary Gland Cystadenomas: A Case Series Study and Literature Review.

IF 3.2 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2024-06-09 DOI:10.1007/s12105-024-01661-2

João Paulo Gonçalves de Paiva, Daniela Giraldo Roldán, Hélen Kaline Farias Bezerra, Alan Roger Santos-Silva, Márcio Ajudarte Lopes, Pablo Agustin Vargas, Jacks Jorge

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引用次数: 0

Abstract

Background: Salivary gland cystadenoma (SGCA) is a rare benign tumor that predominantly occurs in the parotid gland. SGCAs affecting the minor salivary glands are uncommon and often resemble, clinically and histopathologically, other salivary gland lesions.

Methods: This study aimed to describe a series of four cases of SGCA affecting intraoral sites and performed a literature review of well-reported SGCA published in the English-language literature.

Results: SGCA cases included in this series were diagnosed in the buccal mucosa, lip, and hard palate of female patients aged between 19 and 78 years. All cases underwent excisional biopsy and were histologically characterized by a multicystic growth with variable degrees of capsule formation and were lined by several types of epithelium, including some cell types that are infrequently reported in SGCA. In some cases, a small collection of lymphocytes was observed adjacent to cystic formations. All SGCA were positive for periodic acid-Schiff, and immunohistochemical reactions were positive for CK7 and p63. The follow-up time ranged widely from 3 to 53 months, and to date, no recurrence has been observed.

Conclusion: The literature review revealed a total of 33 published studies accounting for 55 SGCA cases.

查看原文本刊更多论文

口内唾液腺囊腺瘤：病例系列研究与文献综述。

背景：唾液腺囊腺瘤（SGCA）是一种罕见的良性肿瘤，主要发生在腮腺。影响小唾液腺的 SGCA 并不常见，在临床和组织病理学上往往与其他唾液腺病变相似：本研究旨在描述一系列影响口腔内部位的四例 SGCA 病例，并对英文文献中发表的报道较多的 SGCA 病例进行文献综述：本系列研究中的SGCA病例均被诊断为口腔粘膜、唇部和硬腭部位的SGCA，女性患者的年龄在19岁至78岁之间。所有病例均接受了切除活检，组织学特征为多囊性生长，有不同程度的囊膜形成，内衬为多种类型的上皮细胞，包括一些在 SGCA 中鲜有报道的细胞类型。在某些病例中，还可观察到少量淋巴细胞聚集在囊状组织附近。所有 SGCA 均呈周期性酸-Schiff 阳性，免疫组化反应呈 CK7 和 p63 阳性。随访时间从 3 个月到 53 个月不等，至今未发现复发：文献综述显示共有 33 项已发表的研究，涉及 55 例 SGCA 病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.