Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review

IF 6.9 3区医学 Q1 CHEMISTRY, MEDICINAL

Archives of Pharmacal Research Pub Date : 2024-06-08 DOI:10.1007/s12272-024-01500-6

Ping Wang, Xiaomei Huang, Chenyuan Jiang, Rushuang Yang, Jialing Wu, Yinghui Liu, Shuangshuang Feng, Tingting Wang

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Abstract

The oceans are rich in diverse microorganisms, animals, and plants. This vast biological complexity is a major source of unique secondary metabolites. In particular, marine fungi are a promising source of compounds with unique structures and potent antibacterial properties. Over the last decade, substantial progress has been made to identify these valuable antibacterial agents. This review summarizes the chemical structures and antibacterial activities of 223 compounds identified between 2012 and 2023. These compounds, effective against various bacteria including drug-resistant strains such as methicillin-resistant Staphylococcus aureus, exhibit strong potential as antibacterial therapeutics. The review also highlights the relevant challenges in transitioning from drug discovery to product commercialization. Emerging technologies such as metagenomics and synthetic biology are proposed as viable solutions. This paper sets the stage for further research on antibacterial compounds derived from marine fungi and advocates a multidisciplinary approach to combat drug-resistant bacteria.

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2012 年至 2023 年间报道的海洋真菌天然产品的抗菌特性：综述。

海洋中蕴藏着丰富多样的微生物、动物和植物。这种巨大的生物复杂性是独特次生代谢物的主要来源。特别是，海洋真菌是具有独特结构和强效抗菌特性的化合物的重要来源。过去十年中，在鉴定这些宝贵的抗菌剂方面取得了重大进展。本综述总结了 2012 年至 2023 年间发现的 223 种化合物的化学结构和抗菌活性。这些化合物对各种细菌（包括耐药菌株，如耐甲氧西林金黄色葡萄球菌）有效，具有很强的抗菌治疗潜力。综述还强调了从药物发现过渡到产品商业化的相关挑战。本文提出了元基因组学和合成生物学等新兴技术作为可行的解决方案。本文为进一步研究从海洋真菌中提取的抗菌化合物奠定了基础，并倡导采用多学科方法来对抗耐药细菌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Pharmacal Research 医学-药学

CiteScore

13.40

自引率

9.00%

发文量

审稿时长

3.3 months

期刊介绍： Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.