Yafia Kousin Mirza, Partha Sarathi Bera, Sachin Mohite, Ajeet Kumar Pandey, Milan Bera
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引用次数: 0
Abstract
Silanes, a simple and common hydride source, are emphasized for their chemical stability, neat and easy-to-handle and usually not requiring any precautions upon activation by nickel catalysis. Their hydride donor nature, reacted with ligand tailored nickel complex generates reactive Ni-H species, which is normally more prone to facile addition to the π-bond, thus generating the organonickel intermediate, which can undergo variety of sequential cross-coupling reactions. Notably, recent developments have brought to the forefront π-hydrofunctionalization reactions facilitated by Ni-H catalysis. In addition, the exploitation of suitable chiral ligands has paved the way for the realization of asymmetric hydrofunctionalization reactions in the realm of π-bonds. This review aims to provide an in-depth exploration of the latest achievements in C-C and C-heteroatom bond formations through silane mediated hydrofunctionalization catalyzed by nickel hydride. In particular, the NiH/ligand-catalytic system exhibits remarkable reactivity with π-substrates including alkenes, alkynes, and allenes. A thorough mechanistic understanding of these processes offers insights into the trends and future direction in drive innovation in catalyst design, fine tune reaction systems, and development of new cross-coupling reactions with π-substrates.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.