Predicting Time to Return to Cannabis Use After a Cessation Attempt: Impact of Cumulated Exposure to Nicotine-Containing Products.

IF 2.1 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Tobacco Use Insights Pub Date : 2024-06-05 eCollection Date: 2024-01-01 DOI:10.1177/1179173X241259603
Natalia Poliakova, Lydia A Shrier, Sion Kim Harris, Richard E Bélanger
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Abstract

Objective: Cannabis is frequently co-used with tobacco/nicotine products, especially among young adults. Little is known about the effects of this co-use on cannabis cessation outcomes. Within a sample of young adults using cannabis frequently (current use of ≥5 days/week in the past 3 months), this study aimed to (a) document sources of exposure to tobacco/nicotine products, whether used simultaneously with cannabis or on different occasions, (b) examine if the level of cumulated exposure to tobacco/nicotine (self-reported or from biochemical testing) could predict time to cannabis lapse during a cannabis abstinence period, and (c) explore the relationship between nicotine/tobacco exposure and time to cannabis lapse according to tobacco cigarette smoking status. Method: Urine cotinine measures and self-reported data on use of different tobacco/nicotine products, collected from 32 participants (aged 19 to 23), were analyzed to predict time to lapse during a 2-week period of attempted abstinence from cannabis, controlling for cannabis dependence and sex. Results: Half of participants (56.3%) used at least one tobacco/nicotine product. Higher urine cotinine, representing higher cumulated tobacco/nicotine exposure, was related to a higher risk of lapsing (Hazard Ratio [HR] = 1.64; 95%CI [1.04, 2.58]). The risk of lapsing was even higher ([HR] = 3.46; 95%CI [1.17, 10.25]) among heavily tobacco/nicotine exposed (>600 ng/mL, urine cotinine) participants than among unexposed (<50 ng/mL) or lightly/moderately exposed (50-600 ng/mL) participants. Among those smoking cigarettes (solely or in combination with other products), there was no relation between cotinine level and time to lapse, likely due to a reduced variability in abstinence probability and a high likelihood of lapse observed for higher cotinine levels, mainly achieved by cigarette use. Conclusions: With a rapidly changing landscape of tobacco/nicotine use, our results underscore the need to consider all sources of tobacco/nicotine exposure to fully understand the specific and cumulative contributions of tobacco/nicotine to cannabis cessation outcomes.

预测尝试戒烟后重新吸食大麻的时间:累积接触含尼古丁产品的影响。
目的:大麻经常与烟草/尼古丁产品同时使用,尤其是在年轻人当中。人们对这种共同使用大麻对戒烟效果的影响知之甚少。本研究以经常使用大麻的年轻成年人为样本(过去 3 个月内≥5 天/周),旨在 (a) 记录接触烟草/尼古丁产品的来源,无论是与大麻同时使用还是在不同场合使用、(b) 研究烟草/尼古丁累积暴露水平(自我报告或生化检测)是否可以预测戒断大麻期间大麻失效的时间,以及 (c) 根据吸食香烟的状况,探讨尼古丁/烟草暴露与大麻失效时间之间的关系。方法:对从 32 名参与者(19 至 23 岁)处收集的尿液可替宁测量值和关于使用不同烟草/尼古丁产品的自我报告数据进行分析,以预测在尝试戒断大麻的 2 周内失效的时间,同时控制大麻依赖性和性别。结果显示半数参与者(56.3%)至少使用过一种烟草/尼古丁产品。尿液中可替宁含量越高,代表累积的烟草/尼古丁暴露量越高,则失禁风险越高(危险比 [HR] = 1.64;95%CI [1.04,2.58])。烟草/尼古丁暴露严重(尿可替宁>600 ng/mL)的参与者比未暴露者的失效风险更高([HR] = 3.46; 95%CI [1.17, 10.25]):随着烟草/尼古丁使用情况的迅速变化,我们的研究结果突出表明有必要考虑所有的烟草/尼古丁暴露来源,以充分了解烟草/尼古丁对戒除大麻结果的具体和累积影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tobacco Use Insights
Tobacco Use Insights PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
自引率
4.50%
发文量
32
审稿时长
8 weeks
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