Alpha-linolenic acid selectively inhibits the contraction of pig coronary arteries mediated through prostanoid TP receptors

IF 3 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of pharmacological sciences Pub Date : 2024-06-04 DOI:10.1016/j.jphs.2024.06.001

Kento Yoshioka , Keisuke Obara , Mikoto Ozawa, Mayu Kiguchi, Yuri Nakao, Hinako Miyaji, Toma Yamashita, Noboru Saitoh, Yutaka Nakagome, Yoshio Tanaka

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Abstract

We examined the inhibitory effects of α-linolenic acid (ALA) on the contractions of pig coronary arteries. ALA concentration-dependently inhibited the contractions elicited by U46619 and prostaglandin F_2α without affecting those elicited by 80 mM KCl, histamine, acetylcholine, and serotonin. ALA rightward shifted the concentration-response curve of U46619, and Schild plot analysis revealed that ALA competitively antagonized U46619. Furthermore, ALA inhibited the increase in intracellular Ca²⁺ concentration caused by TP receptor stimulation but not that caused by FP receptor stimulation. These results suggest that ALA behaves as a selective antagonist of TP receptors in coronary arteries.

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α-亚麻酸选择性抑制通过前列腺素 TP 受体介导的猪冠状动脉收缩

我们研究了α-亚麻酸（ALA）对猪冠状动脉收缩的抑制作用。ALA 浓度依赖性地抑制 U46619 和前列腺素 F2α 引起的收缩，而不影响 80 mM KCl、组胺、乙酰胆碱和血清素引起的收缩。ALA 使 U46619 的浓度-反应曲线右移，Schild plot 分析显示 ALA 竞争性地拮抗了 U46619。此外，ALA 可抑制 TP 受体刺激引起的细胞内 Ca2+ 浓度升高，但不能抑制 FP 受体刺激引起的细胞内 Ca2+ 浓度升高。这些结果表明，ALA 是冠状动脉中 TP 受体的一种选择性拮抗剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.