Determinants of Metastatic Colorectal Cancer With Permanent Liver- Limited Disease

IF 3.3 3区医学 Q2 ONCOLOGY

Clinical colorectal cancer Pub Date : 2024-09-01 DOI:10.1016/j.clcc.2024.05.010

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引用次数: 0

Abstract

Colorectal cancer (CRC) is a complex and genetically heterogeneous disease presenting a specific metastatic pattern, with the liver being the most common site of metastasis. Around 20%-25% of patients with CRC will develop exclusively hepatic metastatic disease throughout their disease history. With its specific characteristics and therapeutic options, liver-limited disease (LLD) should be considered as a specific entity. The identification of these patients is particularly relevant in view of the growing interest in liver transplantation in selected patients with advanced CRC. Identifying why some patients will develop only LLD remains a challenge, mainly because of a lack of a systemic understanding of this complex and interlinked phenomenon given that cancer has traditionally been investigated according to distinct physiological compartments. Recently, multidisciplinary efforts and new diagnostic tools have made it possible to study some of these complex issues in greater depth and may help identify targets and specific treatment strategies to benefit these patients. In this review we analyze the underlying biology and available tools to help clinicians better understand this increasingly common and specific disease.

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肝脏永久受限的转移性结直肠癌的决定因素

结肠直肠癌（CRC）是一种复杂的遗传异质性疾病，具有特殊的转移模式，肝脏是最常见的转移部位。约有 20%-25% 的 CRC 患者在整个病史中只会出现肝转移性疾病。肝局限性疾病（LLD）具有特殊的特征和治疗选择，应被视为一种特殊的疾病。鉴于人们越来越关注对选定的晚期 CRC 患者进行肝移植，对这些患者进行鉴别就显得尤为重要。鉴别某些患者为何仅发展为肝局限性疾病仍是一项挑战，这主要是因为人们对这一复杂而又相互关联的现象缺乏系统的了解，而癌症历来是根据不同的生理分区进行研究的。最近，多学科的努力和新的诊断工具使得对其中一些复杂问题进行更深入的研究成为可能，并可能有助于确定靶点和特定的治疗策略，使这些患者受益。在这篇综述中，我们分析了潜在的生物学和可用工具，以帮助临床医生更好地了解这种日益常见的特殊疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical colorectal cancer 医学-肿瘤学

CiteScore

5.50

自引率

2.90%

发文量

审稿时长

27 days

期刊介绍： Clinical Colorectal Cancer is a peer-reviewed, quarterly journal that publishes original articles describing various aspects of clinical and translational research of gastrointestinal cancers. Clinical Colorectal Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of colorectal, pancreatic, liver, and other gastrointestinal cancers. The main emphasis is on recent scientific developments in all areas related to gastrointestinal cancers. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.