ANALYZE-AD: A comparative analysis of novel AI approaches for early Alzheimer’s detection

Abstract

Alzheimer’s disease, characterized by progressive and irreversible deterioration of cognitive functions, represents a significant health concern, particularly among older adults, as it stands as the foremost cause of dementia. Despite its debilitating nature, early detection of Alzheimer’s disease holds considerable advantages for affected individuals. This study investigates machine-learning methodologies for the early diagnosis of Alzheimer’s disease, utilizing datasets sourced from OASIS and ADNI. The initial classification methods consist of a 5-class ADNI classification and a 3-class OASIS classification. Three unique methodologies encompass binary-class inter-dataset models, which involve training on a single dataset and subsequently testing on another dataset for both ADNI and OASIS datasets. Additionally, a hybrid dataset model is also considered. The proposed methodology entails the concatenation of both datasets, followed by shuffling and subsequently conducting training and testing on the amalgamated dataset. The findings demonstrate impressive levels of accuracy, as Light Gradient Boosting Machine (LGBM) achieved a 99.63% accuracy rate for 5-class ADNI classification and a 95.75% accuracy rate by Multilayer Perceptron (MLP) for 3-class OASIS classification, both when hyperparameter tweaking was implemented. The K-nearest neighbor algorithm demonstrated exceptional performance, achieving an accuracy of 87.50% in ADNI-OASIS (2 Class) when utilizing the Select K Best method. The Gaussian Naive Bayes algorithm demonstrated exceptional performance in the OASIS-ADNI approach, attaining an accuracy of 77.97% using Chi-squared feature selection. The accuracy achieved by the Hybrid method, which utilized LGBM with hyperparameter optimization, was 99.21%. Furthermore, the utilization of Explainable AI approaches, particularly Lime, was implemented in order to augment the interpretability of the model.