The Prognostic Role of Prognostic Nutritional Index and Controlling Nutritional Status in Predicting Survival in Older Adults with Oncological Disease: A Systematic Review

Onco Pub Date : 2024-06-02 DOI:10.3390/onco4020009

Ana Filipa Ferreira, Tatiana Fernandes, Maria do Carmo Carvalho, Helena Soares Loureiro

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Abstract

The increase in new cancer diagnoses in the elderly calls for new, accessible, and easy-to-use prognostic tools that contribute to lowering the burden of the disease. Recognising the importance of inflammation and nutritional status in the progression of the disease, the purpose of this systematic review was to synthesise the evidence on the prognostic role of Prognostic Nutritional Index (PNI) and Controlling Nutritional Status (CONUT) in predicting survival of older adult cancer patients. A comprehensive search was conducted in PubMed and Web of Science Core Collection databases until 22 February 2024. The articles included in this review (n = 38) examined the relationships of PNI and CONUT with survival outcomes in elderly cancer patients. Despite high heterogeneity between the studies, most concluded that low PNI values are associated with poor overall survival (OS), particularly in gastric cancer patients. Most studies did not find an association between PNI and cancer-specific survival, progression-free survival, disease-free survival, recurrence-free survival, and mortality. Results regarding the prognostic role of CONUT in predicting survival were inconclusive. This study suggests that PNI could be used to predict OS in elderly cancer patients, while more studies are needed to assess the prognostic role of CONUT.

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预后营养指数和控制营养状况在预测老年肿瘤患者生存期中的预后作用：系统综述

新诊断出的老年癌症患者越来越多，这就需要有新的、方便易用的预后工具来降低疾病负担。认识到炎症和营养状况在疾病进展中的重要性，本系统综述旨在综合预后营养指数（PNI）和控制营养状况（CONUT）在预测老年癌症患者生存率方面的预后作用的证据。截至 2024 年 2 月 22 日，我们在 PubMed 和 Web of Science 核心数据库中进行了全面检索。本综述收录的文章（n = 38）研究了 PNI 和 CONUT 与老年癌症患者生存结果的关系。尽管研究之间存在高度异质性，但大多数研究认为，低 PNI 值与总生存期（OS）差有关，尤其是在胃癌患者中。大多数研究并未发现 PNI 与癌症特异性生存、无进展生存、无疾病生存、无复发生存和死亡率之间存在关联。关于 CONUT 在预测生存率方面的预后作用，研究结果尚无定论。本研究表明，PNI 可用于预测老年癌症患者的 OS，而 CONUT 的预后作用则需要更多的研究来评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Onco

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