Multiple Sampling Capsule Robot for Studying Gut Microbiome

Sanghyeon Park, M. Hoang, Jayoung Kim, Sukho Park
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Abstract

Longitudinal analysis of the gut microbiota is crucial for understanding its relationship with gastrointestinal (GI) diseases and advancing diagnostics and treatments. Most ingestible sampling devices move passively within the GI tract, rely on physiological factors, and fail at multipoint sampling. This study proposes a multiple‐sampling capsule robot capable of collecting gut microbiota from various locations within the GI tract with minimal cross‐contamination. The proposed capsule comprises a body, a driving unit, six sampling tools, a central rod, and two heads. Electromagnetic field control facilitates control of the orientation and position of the capsule, particularly to align the channel of the capsule where the sample is collected facing downward. The capsule can collect six gut microbiota samples preventing contamination before and after sampling. The active locomotion and multiple sampling performance of the capsule are evaluated through basic performance tests (propulsion direction precision: 0.76 ± 0.52°, channel alignment precision: 0.84 ± 0.55°), phantom tests (average amount per sample: 10.3 ± 2.4 mg, cross‐contamination: 0.6 ± 0.4%), and ex‐vivo tests (average amount per sample: 9.9 ± 1.7 mg). The possibility of integration and clinical application of the capsule is confirmed through preclinical tests using a porcine model.
用于研究肠道微生物组的多采样胶囊机器人
对肠道微生物群进行纵向分析,对于了解其与胃肠道(GI)疾病的关系以及促进诊断和治疗至关重要。大多数可摄取的采样设备在胃肠道内被动移动,依赖于生理因素,并且无法进行多点采样。本研究提出了一种多点采样胶囊机器人,能够从消化道内不同位置采集肠道微生物群,并将交叉污染降至最低。拟议的胶囊由一个主体、一个驱动单元、六个采样工具、一根中心杆和两个头组成。电磁场控制有助于控制胶囊的方向和位置,特别是使胶囊采集样本的通道朝下。胶囊可采集六个肠道微生物群样本,防止采样前后的污染。通过基本性能测试(推进方向精度:0.76 ± 0.52°,通道对齐精度:0.84 ± 0.55°)、模型测试(平均每个样本量:10.3 ± 2.4 毫克,交叉污染:0.6 ± 0.4%)和体外测试(平均每个样本量:9.9 ± 1.7 毫克),对胶囊的主动运动和多重采样性能进行了评估。通过使用猪模型进行临床前试验,证实了胶囊整合和临床应用的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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