On the specificity of the immunoglobulin G produced by chickens experimentally infected with Marek's disease virus.

Abstract

In chickens experimentally infected with Marek's Disease virus (MDV) an increased amount of immunoglobulin G is produced. Using a technique of quantitative crossed immunoelectrophoresis it has been shown, that 70% of this immunoglobulin G is non-specific. Only 18% could be absorbed with MDV strain CPRL VII-infected chicken kidney cells, and only 5% with MDV-induced lymphoblastoid cells of the MDCC-MSB1 cell line. It is hypothesized that the production the unspecific immunoglobulin G is caused by a polyclonal stimulation of B-cells.