Spontaneous Tumor Regression and Reversion: Insights and Associations with Reduced Dietary Phosphate

Cancers Pub Date : 2024-06-03 DOI:10.3390/cancers16112126
Ronald B. Brown
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Abstract

Tumors that spontaneously shrink from unknown causes in tumor regression, and that return to normal cells in tumor reversion, are phenomena with the potential to contribute new knowledge and novel therapies for cancer patient survival. Tumorigenesis is associated with dysregulated phosphate metabolism and an increased transport of phosphate into tumor cells, potentially mediated by phosphate overload from excessive dietary phosphate intake, a significant problem in Western societies. This paper proposes that reduced dietary phosphate overload and reregulated phosphate metabolism may reverse an imbalance of kinases and phosphatases in cell signaling and cellular proliferation, thereby activating autophagy in tumor regression and reversion. Dietary phosphate can also be reduced by sickness-associated anorexia, fasting-mimicking diets, and other diets low in phosphate, all of which have been associated with tumor regression. Tumor reversion has also been demonstrated by transplanting cancer cells into a healthy microenvironment, plausibly associated with normal cellular phosphate concentrations. Evidence also suggests that the sequestration and containment of excessive phosphate within encapsulated tumors is protective in cancer patients, preventing the release of potentially lethal amounts of phosphate into the general circulation. Reducing dietary phosphate overload has the potential to provide a novel, safe, and effective reversion therapy for cancer patients, and further research is warranted.
自发性肿瘤消退和逆转:膳食磷酸盐减少的启示与关联
在肿瘤消退过程中,不明原因的肿瘤会自发缩小;在肿瘤复发过程中,肿瘤细胞会恢复正常,这些现象有可能为癌症患者的生存提供新知识和新疗法。肿瘤发生与磷酸盐代谢失调和进入肿瘤细胞的磷酸盐转运增加有关,这可能是由于饮食中磷酸盐摄入量过多造成的磷酸盐超载,而磷酸盐超载是西方社会的一个重要问题。本文提出,减少膳食中过量的磷酸盐,重新调节磷酸盐代谢,可以扭转细胞信号传导和细胞增殖过程中激酶和磷酸酶的失衡,从而激活肿瘤消退和逆转过程中的自噬作用。疾病引起的厌食、模拟禁食和其他低磷酸盐饮食也可减少饮食中的磷酸盐,所有这些都与肿瘤消退有关。将癌细胞移植到健康的微环境中也证明了肿瘤的逆转,这可能与正常的细胞磷酸盐浓度有关。还有证据表明,将过量的磷酸盐封存和控制在包裹的肿瘤内对癌症患者具有保护作用,可防止可能致命的磷酸盐释放到血液循环中。减少饮食中过量的磷酸盐有可能为癌症患者提供一种新颖、安全、有效的逆转疗法,因此还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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