Exploring the impact of N4-acetylcytidine modification in RNA on non-neoplastic disease: unveiling its role in pathogenesis and therapeutic opportunities.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Keyu Wan, Tiantian Nie, Wenhao Ouyang, Yunjing Xiong, Jing Bian, Ying Huang, Li Ling, Zhenjun Huang, Xianhua Zhu
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引用次数: 0

Abstract

RNA modifications include not only methylation modifications, such as m6A, but also acetylation modifications, which constitute a complex interaction involving "writers," "readers," and "erasers" that play crucial roles in growth, genetics, and disease. N4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification that plays a profound role in the pathogenesis of a wide range of diseases. This review provides insights into the functional impact of ac4C modifications in disease and introduces new perspectives for disease treatment. These studies provide important insights into the biological functions of post-transcriptional RNA modifications and their potential roles in disease mechanisms, offering new perspectives and strategies for disease treatment.

探索 RNA 中 N4-乙酰胞嘧啶修饰对非肿瘤性疾病的影响:揭示其在发病机制中的作用和治疗机会。
RNA 修饰不仅包括甲基化修饰(如 m6A),还包括乙酰化修饰,它们构成了一种复杂的相互作用,涉及 "写者"、"读者 "和 "擦除者",在生长、遗传和疾病中发挥着至关重要的作用。N4-乙酰胞苷(ac4C)是一种古老而高度保守的 RNA 修饰,在多种疾病的发病机制中发挥着深远的作用。本综述深入探讨了 ac4C 修饰在疾病中的功能性影响,并为疾病治疗提供了新的视角。这些研究为了解转录后 RNA 修饰的生物学功能及其在疾病机制中的潜在作用提供了重要见解,为疾病治疗提供了新的视角和策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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