Aerobic Exercise Ameliorates Cognitive Disorder and Declined Oxidative Stress via Modulating the Nrf2 Signaling Pathway in d-galactose Induced Aging Mouse Model

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemical Research Pub Date : 2024-06-06 DOI:10.1007/s11064-024-04164-2

Guangjing Xie, Zixuan Xu, Feizhou Li, Meng Kong, Ping Wang, Yuping Shao

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Abstract

The aim of this research was to explore the potential of treadmill exercise in preventing brain aging and neurodegenerative diseases caused by oxidative stress, by studying its effects on d-galactose-induced mice and the mechanisms involved. The results showed that C57BL/6 mice induced with d-gal exhibited cognitive impairment and oxidative stress damage, which was ameliorated by treadmill exercise. The Morris water maze also showed that exercise improved cognitive performance in aging mice and alleviated hippocampal and mitochondrial damage. The study also found that treadmill exercise increased the expression of nuclear factor Nrf2, p-GSK3β, HO-1, NQO1, BDNF, and Bcl-2 proteins while decreasing the expression of Bax. Furthermore, there was a substantial increase in the levels of CAT, GSH-PX and SOD in the serum, along with a decrease in MDA levels. The outcomes propose that aerobic exercise has the potential to hinder oxidative stress and cell death in mitochondria through the modulation of the Nrf2/GSK3β signaling pathway, thus improving cognitive impairment observed in the aging model induced by d-galactose. It appears that treadmill exercise could potentially serve as an effective therapeutic approach to mitigating brain aging and neurodegenerative diseases triggered by oxidative stress.

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有氧运动通过调节 D-半乳糖诱导衰老小鼠模型的 Nrf2 信号通路改善认知障碍和氧化应激下降

本研究旨在通过研究跑步机运动对D-半乳糖诱导的小鼠的影响及其机制，探索跑步机运动在预防氧化应激引起的脑衰老和神经退行性疾病方面的潜力。结果表明，D-半乳糖诱导的C57BL/6小鼠表现出认知障碍和氧化应激损伤，而跑步机运动可改善这些症状。莫里斯水迷宫也表明，运动能改善衰老小鼠的认知能力，减轻海马和线粒体损伤。研究还发现，跑步机运动增加了核因子Nrf2、p-GSK3β、HO-1、NQO1、BDNF和Bcl-2蛋白的表达，同时降低了Bax的表达。此外，血清中 CAT、GSH-PX 和 SOD 的水平也有大幅提高，同时 MDA 水平也有所下降。研究结果表明，通过调节 Nrf2/GSK3β 信号通路，有氧运动有可能阻碍线粒体中的氧化应激和细胞死亡，从而改善在 D-半乳糖诱导的衰老模型中观察到的认知障碍。由此看来，跑步机运动有可能成为一种有效的治疗方法，缓解氧化应激引发的大脑衰老和神经退行性疾病。

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.