Mapping where and when necroptotic cell death occurs in disease

IF 13.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Death and Differentiation Pub Date : 2024-06-04 DOI:10.1038/s41418-024-01318-1

Andre L. Samson, James M. Murphy

引用次数: 0

Abstract

A series of recent studies have established where the necroptosis machinery — RIPK1, RIPK3, MLKL, ZBP1 and Caspase-8 — occur and are activated in mouse and human tissues, and how ZBP1 splicing might regulate necroptosis. These studies highlight the importance of mapping necroptosis spatially to understand how pathway dysregulation can lead to disease.

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绘制疾病中细胞坏死发生的位置和时间图。

最近的一系列研究确定了坏死机制 - - RIPK1、RIPK3、MLKL、ZBP1和Caspase-8 - - 在小鼠和人类组织中发生和激活的位置，以及ZBP1剪接可能如何调控坏死。这些研究凸显了绘制坏死细胞空间图谱以了解通路失调如何导致疾病的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death and Differentiation 生物-生化与分子生物学

CiteScore

24.70

自引率

1.60%

发文量

181

审稿时长

3 months

期刊介绍： Mission, vision and values of Cell Death & Differentiation: To devote itself to scientific excellence in the field of cell biology, molecular biology, and biochemistry of cell death and disease. To provide a unified forum for scientists and clinical researchers It is committed to the rapid publication of high quality original papers relating to these subjects, together with topical, usually solicited, reviews, meeting reports, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.