Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study.

IF 3 3区 医学 Q1 UROLOGY & NEPHROLOGY
Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI:10.1080/0886022X.2024.2357746
Wenjie Dong, Qiuyu Li, Lei Chen, Hui Tang, Kun Tu, Li Luo, Longyang Jiang, Yilan Huang
{"title":"Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study.","authors":"Wenjie Dong, Qiuyu Li, Lei Chen, Hui Tang, Kun Tu, Li Luo, Longyang Jiang, Yilan Huang","doi":"10.1080/0886022X.2024.2357746","DOIUrl":null,"url":null,"abstract":"<p><p>Numerous studies have revealed a correlation between the risk of developing diabetic nephropathy (DN) and the gut microbiota (GM) composition. However, it remains uncertain whether the GM composition causes DN. We aimed to explore any potential causal links between the GM composition and the risk of developing DN. A meta-analysis conducted by the MiBioGen consortium of the largest genome-wide association study (GWAS) provided aggregated data on the GM. DN data were obtained from the IEU database. The inverse-variance weighting (IVW) method was employed as the primary analytical approach. The IVW analysis indicated that genus <i>Dialister</i> (OR = 0.51, 95% CI: 0.34-0.77, <i>p</i> = 0.00118) was protective against DN. In addition, class <i>Gammaproteobacteria</i> (OR = 0.47, 95% CI: 0.27-0.83, <i>p</i> = 0.0096), class <i>Lentisphaeria</i> (OR =0.76, 95% CI: 0.68-0.99, <i>p</i> = 0.04), order <i>Victivallales</i> (OR = 0.76, 95% CI: 0.58-0.99, <i>p</i> = 0.04), and phylum <i>Proteobacteria</i> (OR = 0.53, 95% CI: 0.33-0.85, <i>p</i> = 0.00872) were negatively associated with the risk of developing DN. Genus <i>LachnospiraceaeUCG008</i> (OR =1.45, 95% CI: 1.08-1.95, <i>p</i> = 0.01), order <i>Bacteroidales</i> (OR = 1.59, 95% CI: 1.02-2.49, <i>p</i> = 0.04), and genus <i>Terrisporobacter</i> (OR = 1.98, 95% CI: 1.14-3.45, <i>p</i> = 0.015) were positively associated with the risk of developing DN. In this study, we established a causal relationship between the genus <i>Dialister</i> and the risk of developing DN. Further trials are required to confirm the protective effects of probiotics on DN and to elucidate the precise protective mechanisms involving genus <i>Dialister</i> and DN.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151794/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Renal Failure","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/0886022X.2024.2357746","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Numerous studies have revealed a correlation between the risk of developing diabetic nephropathy (DN) and the gut microbiota (GM) composition. However, it remains uncertain whether the GM composition causes DN. We aimed to explore any potential causal links between the GM composition and the risk of developing DN. A meta-analysis conducted by the MiBioGen consortium of the largest genome-wide association study (GWAS) provided aggregated data on the GM. DN data were obtained from the IEU database. The inverse-variance weighting (IVW) method was employed as the primary analytical approach. The IVW analysis indicated that genus Dialister (OR = 0.51, 95% CI: 0.34-0.77, p = 0.00118) was protective against DN. In addition, class Gammaproteobacteria (OR = 0.47, 95% CI: 0.27-0.83, p = 0.0096), class Lentisphaeria (OR =0.76, 95% CI: 0.68-0.99, p = 0.04), order Victivallales (OR = 0.76, 95% CI: 0.58-0.99, p = 0.04), and phylum Proteobacteria (OR = 0.53, 95% CI: 0.33-0.85, p = 0.00872) were negatively associated with the risk of developing DN. Genus LachnospiraceaeUCG008 (OR =1.45, 95% CI: 1.08-1.95, p = 0.01), order Bacteroidales (OR = 1.59, 95% CI: 1.02-2.49, p = 0.04), and genus Terrisporobacter (OR = 1.98, 95% CI: 1.14-3.45, p = 0.015) were positively associated with the risk of developing DN. In this study, we established a causal relationship between the genus Dialister and the risk of developing DN. Further trials are required to confirm the protective effects of probiotics on DN and to elucidate the precise protective mechanisms involving genus Dialister and DN.

肠道微生物群与糖尿病肾病之间的关系:双样本孟德尔随机研究。
大量研究表明,糖尿病肾病(DN)的发病风险与肠道微生物群(GM)组成之间存在相关性。然而,目前仍不确定肠道微生物群的组成是否会导致糖尿病肾病。我们的目的是探索肠道微生物群组成与糖尿病肾病发病风险之间的潜在因果关系。MiBioGen联盟对最大的全基因组关联研究(GWAS)进行了荟萃分析,提供了有关GM的汇总数据。DN 数据来自 IEU 数据库。主要分析方法是反方差加权法(IVW)。IVW 分析表明,Dialister 属(OR = 0.51,95% CI:0.34-0.77,p = 0.00118)对 DN 具有保护作用。此外,伽马蛋白菌类(OR = 0.47,95% CI:0.27-0.83,p = 0.0096)、Lentisphaeria 类(OR =0.76,95% CI:0.68-0.99,p = 0.04)、Victivallales 目(OR = 0.76,95% CI:0.58-0.99,p = 0.04)和蛋白菌门(OR = 0.53,95% CI:0.33-0.85,p = 0.00872)与罹患 DN 的风险呈负相关。LachnospiraceaeUCG008属(OR =1.45,95% CI:1.08-1.95,p =0.01)、类杆菌目(OR =1.59,95% CI:1.02-2.49,p =0.04)和Terrisporobacter属(OR =1.98,95% CI:1.14-3.45,p =0.015)与罹患DN的风险呈正相关。在这项研究中,我们确定了 Dialister 菌属与罹患 DN 风险之间的因果关系。要证实益生菌对DN的保护作用,并阐明Dialister属与DN之间的确切保护机制,还需要进一步的试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Renal Failure
Renal Failure 医学-泌尿学与肾脏学
CiteScore
3.90
自引率
13.30%
发文量
374
审稿时长
1 months
期刊介绍: Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信