Medication burden in patients with dialysis-dependent CKD: a systematic review.

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI:10.1080/0886022X.2024.2353341

Xuemei Liu, Ping Chen, Yun Liu, Xiaoyan Jia, Dongmei Xu

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Abstract

This systematic review aimed to statistically profile the medication burden and associated influencing factors, and outcomes in patients with dialysis-dependent chronic kidney disease (DD-CKD). Studies of medication burden in patients with DD-CKD in the last 10 years from 1 January 2013 to 31 March 2024 were searched from PubMed, Embase, and Cochrane databases. Newcastle-Ottawa Scale (NOS) or Agency for Healthcare Research and Quality (AHRQ) methodology checklist was used to evaluate quality and bias. Data extraction and combining from multiple groups of number (n), mean, and standard deviation (SD) were performed using R programming language (version4.3.1; R Core Team, Vienna, Austria). A total of 10 studies were included, and the results showed a higher drug burden in patients with DD-CKD. The combined pill burden was 14.57 ± 7.56 per day in hemodialysis (HD) patients and 14.63 ± 6.32 in peritoneal dialysis (PD) patients. The combined number of medications was 9.74 ± 3.37 in HD and 8 ± 3 in PD. Four studies described the various drug classes and their proportions, in general, antihypertensives and phosphate binders were the most commonly used drugs. Five studies mentioned factors associated with medication burden. A total of five studies mentioned medication burden-related outcomes, with one study finding that medication-related burden was associated with increased treatment burden, three studies finding that poor medication adherence was associated with medication burden, and another study finding that medication complexity was not associated with self-reported medication adherence. Limitations: meta-analysis was not possible due to the heterogeneity of studies.

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透析依赖型慢性肾脏病患者的用药负担：系统综述。

本系统性综述旨在统计透析依赖型慢性肾病（DD-CKD）患者的用药负担、相关影响因素和治疗效果。研究人员在 PubMed、Embase 和 Cochrane 数据库中检索了 2013 年 1 月 1 日至 2024 年 3 月 31 日这 10 年间有关 DD-CKD 患者用药负担的研究。采用纽卡斯尔-渥太华量表（NOS）或美国医疗保健研究与质量机构（AHRQ）方法检查表来评估质量和偏倚。使用 R 编程语言（版本 4.3.1；R 核心小组，奥地利维也纳）进行数据提取并合并多组数字（n）、平均值和标准差（SD）。共纳入了 10 项研究，结果显示 DD-CKD 患者的药物负担较重。血液透析（HD）患者每天的综合药物负担为（14.57 ± 7.56）粒，腹膜透析（PD）患者为（14.63 ± 6.32）粒。血液透析（HD）和腹膜透析（PD）患者的合计药物数量分别为（9.74 ± 3.37）和（8 ± 3）。四项研究描述了各种药物类别及其比例，总的来说，降压药和磷酸盐结合剂是最常用的药物。五项研究提到了与用药负担相关的因素。共有五项研究提到了与用药负担相关的结果，其中一项研究发现与用药相关的负担与治疗负担的增加有关，三项研究发现用药依从性差与用药负担有关，另一项研究发现用药复杂性与自我报告的用药依从性无关。局限性：由于研究的异质性，无法进行荟萃分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.