Longitudinal follow-up of quiescent lens injury secondary to intravitreal antivascular endothelial growth factor injection

Abstract

A longitudinal follow-up of quiescent lens injury caused by intravitreal antivascular endothelial growth factor (VEGF) injection was reported. A 55-year-old man complained of unilateral diplopia in the right eye soon after the fourth intravitreal anti-VEGF injection for macular edema secondary to central retinal vein occlusion elsewhere. At presentation, ophthalmic examination revealed an evident track-like posterior capsule damage of the lens accompanied by clustered lens epithelial cell proliferation along each side of the posterior capsule break, yet without subcapsular cataract formation. At the 3-month follow-up, slitlamp examination showed a bit denser track-like opacification of the posterior lenticular capsule that was surrounded by mild disc-like posterior capsular opacification. Over another 3 months of follow-up, the posterior capsule damage kept stable. Although rare, quiescent lens injury might occur after intravitreal anti-VEGF injection, attention should also be paid to the lens besides fundus conditions when patients complained of visual disturbance soon after uneventful intravitreal injections.