Intracellular bicarbonate and pH of skeletal muscle in chronic renal failure.

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

A Guariglia, C Antonucci, E Coffrini, S Del Canale, E Fiaccadori, F Reni, P Vitali, U Arduini, A Borghetti

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Abstract

In 11 controls and 10 patients suffering from untreated uraemic acidosis intracellular bicarbonate and skeletal muscle pH (needle biopsy) were determined. In all patients a significant intracellular acidosis, not related to any extracellular indices was found. It is concluded that the chronic proton load is able to effect intracellular buffer composition; moreover the action of other factors such as derangements of cell metabolism and nutritional imbalance could be operating.

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慢性肾衰竭时骨骼肌细胞内碳酸氢盐和pH的变化。

在11名对照组和10名未经治疗的尿毒性酸中毒患者中，测定了细胞内碳酸氢盐和骨骼肌pH值(针活检)。所有患者均有明显的细胞内酸中毒，与任何细胞外指标无关。结果表明，慢性质子负荷能够影响细胞内缓冲液的组成;此外，细胞代谢紊乱、营养失衡等其他因素也可能起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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