Analytical parameterization of Bragg curves for proton beams in muscle, bone, and polymethylmethacrylate.

IF 1.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Radiological Physics and Technology Pub Date : 2024-09-01 Epub Date: 2024-06-01 DOI:10.1007/s12194-024-00816-8
Behzad Aminafshar, Hamid Reza Baghani, Ali Asghar Mowlavi
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引用次数: 0

Abstract

Proton dose calculation in media other than water may be of interest for either research purposes or clinical practice. Current study aims to quantify the required parameters for analytical proton dosimetry in muscle, bone, and PMMA. Required analytical dosimetry parameters were extracted from ICRU-49 report and Janni study. Geant4 Toolkit was also used for Bragg curve simulation inside the investigated media at different proton energies. Calculated and simulated dosimetry data were compared using gamma analysis. Simulated and calculated Bragg curves are consistent, a fact that confirms the validity of reported parameters for analytical proton dosimetry inside considered media. Furthermore, derived analytical parameters for these media are different from those of water. Listed parameters can be reliably utilized for analytical proton dosimetry inside muscle, bone, and PMMA. Furthermore, accurate proton dosimetry inside each medium demands dedicated analytical parameters and one is not allowed to use the water coefficients for non-water media.

质子束在肌肉、骨骼和聚甲基丙烯酸甲酯中的布拉格曲线分析参数化。
在水以外的介质中计算质子剂量可能对研究目的或临床实践有意义。目前的研究旨在量化肌肉、骨骼和 PMMA 中质子剂量分析所需的参数。从 ICRU-49 报告和 Janni 研究中提取了所需的分析剂量测定参数。Geant4 工具包还用于在不同质子能量下对所研究介质内部的布拉格曲线进行模拟。利用伽马分析比较了计算和模拟的剂量测定数据。模拟和计算的布拉格曲线是一致的,这证实了所报告的质子剂量测定分析参数在所考虑介质中的有效性。此外,这些介质的分析参数与水的分析参数不同。列出的参数可以可靠地用于肌肉、骨骼和 PMMA 内部的质子剂量分析。此外,在每种介质中进行准确的质子剂量测定都需要专用的分析参数,不能将水系数用于非水介质。
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来源期刊
Radiological Physics and Technology
Radiological Physics and Technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
12.50%
发文量
40
期刊介绍: The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.
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