Echocardiographic assessment of cardiac function abnormalities and related risk factors in Thai overweight and obese children.

IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Annals of Pediatric Cardiology Pub Date : 2023-11-01 Epub Date: 2024-04-23 DOI:10.4103/apc.apc_134_23
Darunwan Nimpum, Worawan Jittham
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引用次数: 0

Abstract

Background: Childhood obesity has become a global concern, with its prevalence steadily increasing over the past decade. This condition negatively impacts the cardiovascular system, increasing the risk of morbidity and mortality in adulthood. This study aimed to identify cardiac function abnormalities and related risk factors among overweight and obese Thai children.

Materials and methods: A cross-sectional observational study of 70 children with body mass index (BMI) >1 standard deviation above the mean for Thai children was conducted at Naresuan University Hospital. Body fat percentage (%Fat) was measured, and standard transthoracic echocardiography was performed. Metabolic profiles were collected from medical records.

Results: The thickness and diameter of the Left ventricle (LV) wall, including the LV posterior wall, LV internal diameter, and interventricular septum (IVS), were significantly increased in both systolic and diastolic phases in obese children. LV concentric hypertrophy and an abnormal E/E' ratio were found in 27% and 34.3% of participants, respectively. Right ventricular systolic dysfunction indicated by abnormal tricuspid annular plane systolic excursion values was found in 55.7% of all participants. In addition, 27.1% of all obese children had pulmonary hypertension. Significant differences in BMI and %Fat were detected between children with abnormal and normal IVS diastolic (IVSd) (P = 0.016). Our univariate and multivariate correlation analyses revealed a significant positive association between abnormal IVSd and %Fat, with an odd ratio (OR) of 1.13 (95% confidence interval [CI]: 1.01-1.27; P = 0.047) and an adjusted OR of 1.17 (95% CI: 1.01-1.36; P = 0.04).

Conclusions: Cardiac function abnormalities in childhood obesity exhibit a significant positive correlation with BMI and various cardiac dimensions, including ventricular wall thickness. One important related risk factor for increased IVS thickness is %Fat. Therefore, multidisciplinary management of obesity should be initiated as early as possible to prevent future cardiovascular morbidity and mortality.

泰国超重和肥胖儿童心脏功能异常及相关风险因素的超声心动图评估。
背景:儿童肥胖症已成为全球关注的问题,其发病率在过去十年中稳步上升。这种情况会对心血管系统产生负面影响,增加成年后发病和死亡的风险。本研究旨在确定泰国超重和肥胖儿童的心脏功能异常及相关风险因素:纳瑞宣大学医院对 70 名体重指数(BMI)高于泰国儿童平均值 1 个标准差的儿童进行了横断面观察研究。测量了体脂率(%Fat),并进行了标准的经胸超声心动图检查。从医疗记录中收集了代谢概况:结果:肥胖儿童左心室壁(包括左心室后壁、左心室内径和室间隔)的厚度和直径在收缩期和舒张期均显著增加。分别有 27% 和 34.3% 的参与者发现左心室同心性肥厚和 E/E' 比值异常。55.7%的参与者发现右心室收缩功能障碍,表现为三尖瓣环平面收缩期偏移值异常。此外,27.1%的肥胖儿童患有肺动脉高压。IVS舒张期(IVSd)异常和正常的儿童在体重指数(BMI)和脂肪率(%Fat)方面存在显著差异(P = 0.016)。我们的单变量和多变量相关分析显示,IVSd异常与脂肪率之间存在显著的正相关,奇异比(OR)为1.13(95% 置信区间[CI]:1.01-1.27;P = 0.047),调整后的OR为1.17(95% 置信区间:1.01-1.36;P = 0.04):结论:儿童肥胖症的心脏功能异常与体重指数和各种心脏尺寸(包括心室壁厚度)呈显著正相关。心室壁厚度增加的一个重要相关风险因素是脂肪率。因此,应尽早对肥胖症进行多学科管理,以预防未来心血管疾病的发病率和死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Pediatric Cardiology
Annals of Pediatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
1.40
自引率
14.30%
发文量
51
审稿时长
23 weeks
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