Treatment adherence rates across different psychiatric disorders and settings: findings from a large patient cohort.

IF 2.1 3区 医学 Q3 PHARMACOLOGY & PHARMACY
Nicolaja Girone, Maddalena Cocchi, Francesco Achilli, Edoardo Grechi, Chiara Vicentini, Beatrice Benatti, Matteo Vismara, Alberto Priori, Bernardo Dell'Osso
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引用次数: 0

Abstract

Approximately 50% of patients with psychiatric disorders do not fully adhere to the prescribed psychopharmacological therapy, significantly impacting the progression of the disorder and the patient's quality of life. The present study aimed to assess potential differences in terms of rates and clinical features of treatment adherence in a large cohort of psychiatric patients with different diagnoses attending various psychiatric services. The study included 307 psychiatric patients diagnosed with a primary major depressive disorder, bipolar disorder, anxiety disorder, schizophrenic spectrum disorder, or personality disorder. Patient's adherence to treatment was evaluated using the Clinician Rating Scale, with a cutoff of at least five defining adherence subgroups. One-third of the sample reported poor medication adherence. A lower rate of adherence emerged among patients with schizophrenic spectrum disorder and bipolar disorder. Subjects with poor adherence were more frequently inpatients and showed higher current substance use, a greater number of previous hospitalizations, and more severe scores at psychopathological assessment compared with patients with positive adherence. Poor adherence was associated with symptom severity and increased rates of relapses and rehospitalizations. In addition, substance use appears to be an unfavorable transdiagnostic factor for treatment adherence.

不同精神疾病和环境下的治疗依从率:一个大型患者队列的研究结果。
约有 50%的精神病患者不能完全遵照处方接受精神药物治疗,这严重影响了病情的发展和患者的生活质量。本研究旨在评估一大批接受各种精神科服务的不同诊断的精神病患者在坚持治疗的比例和临床特征方面的潜在差异。研究对象包括 307 名被诊断为原发性重度抑郁障碍、双相情感障碍、焦虑障碍、精神分裂症谱系障碍或人格障碍的精神病患者。患者的治疗依从性采用临床医师评分量表进行评估,以至少5分为分界点划分依从性亚组。样本中有三分之一的患者表示服药依从性较差。精神分裂症谱系障碍和双相情感障碍患者的依从性较低。与依从性良好的患者相比,依从性差的患者更经常住院,目前使用药物的比例更高,以前住院的次数更多,精神病理学评估的评分更严重。依从性差与症状严重程度、复发率和再住院率增加有关。此外,药物使用似乎是影响治疗依从性的一个不利的跨诊断因素。
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来源期刊
CiteScore
4.40
自引率
23.10%
发文量
97
审稿时长
>12 weeks
期刊介绍: International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.
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