Laurel Stell, Kent Heberer, Kyung Min Lee, Shoa Clarke, Wu Fan, Ilana Belitskaya-Levy, Julie A. Lynch, Hua Tang, Marijana Vujkovic, Donald Miller, Themistocles L. Assimes, Phil Tsao, Scott Damrauer, Kyong-mi Chang, Jennifer S. Lee, the VA Million Veteran Program
{"title":"Non-glycemic genetic effects on HbA1c and clinical glycemic status in African ancestry: VA Million Veteran Program","authors":"Laurel Stell, Kent Heberer, Kyung Min Lee, Shoa Clarke, Wu Fan, Ilana Belitskaya-Levy, Julie A. Lynch, Hua Tang, Marijana Vujkovic, Donald Miller, Themistocles L. Assimes, Phil Tsao, Scott Damrauer, Kyong-mi Chang, Jennifer S. Lee, the VA Million Veteran Program","doi":"10.1101/2024.05.26.24307947","DOIUrl":null,"url":null,"abstract":"<strong>IMPORTANCE</strong> Clinical guidelines recommend against using glycated hemoglobin A1c (HbA1c) to assess glycemia in patients with two erythropoietic conditions: glucose-6-phosphate dehydrogenase (G6PD) deficiency or sickle cell disease. What remains elusive is quantifying the impact of genetic variants underlying these and other erythropoietic conditions on HbA1c levels as a clinical indicator of glycemic status.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"35 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.05.26.24307947","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
IMPORTANCE Clinical guidelines recommend against using glycated hemoglobin A1c (HbA1c) to assess glycemia in patients with two erythropoietic conditions: glucose-6-phosphate dehydrogenase (G6PD) deficiency or sickle cell disease. What remains elusive is quantifying the impact of genetic variants underlying these and other erythropoietic conditions on HbA1c levels as a clinical indicator of glycemic status.
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