Correlation between White Matter Changes and Clinical Symptoms in Patients with Major Depressive Disorder

IF 0.5 4区医学 Q4 NEUROSCIENCES

Neurochemical Journal Pub Date : 2024-05-27 DOI:10.1134/s181971242402017x

Fei Fei Zhao, Yi Chang Jin, Xin Liang Chen

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Abstract

To analyse the structural characteristics and fibre integrity of white matter in patients with major depressive disorder (MDD) and its relationship with depressive symptoms. Patients with MDD admitted to Wenzhou Seventh People’ Hospital between September 2021 and May 2023 were recruited as participants in the experimental group, and healthy volunteers matching in gender, age and years of education were recruited during the same period as the control group. The two groups were compared in terms of fractional anisotropy (FA), mean diffusivity (MD) and axial diffusivity (AD). The relationship between the white matter volume and the values of FA, MD and AD in different brain regions and the severity of depressive symptoms in the experimental group was analysed. Fifty-eight patients were included in the experimental group, and 60 healthy controls in the control group. In the experimental group, the white matter volume of the right inferior frontal gyrus was negatively correlated with the Hamilton depression rating scale (HAMD-17) score (r = ‒0.355, P < 0.05), and the left parietal gyrus was negatively correlated with the HAMD-17 score (r = –0.361, P < 0.05). The FA value in the occipital radiations of the corpus callosum of the white matter was negatively correlated with the HAMD-17 score (r = –0.410, P < 0.05). Moreover, the MD value of the left and right anterior thalamic radiation of white matter was negatively correlated with the HAMD-17 score (r = –0.389, P < 0.05; r = –0.489, P < 0.01, respectively), and the AD value showed a negative correlation with the HAMD-17 score (r = –0.446, –0.405, respectively, both P < 0.05). Patients with MDD suffer from decreased white matter volume and impaired fibre integrity of white matter, including in the parietal lobe, corpus callosum, corticospinal tract and inferior longitudinal tract. Abnormalities in white matter structure and fibre integrity have a close bearing on the severity of MDD.

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重度抑郁症患者的白质变化与临床症状之间的相关性

摘要分析重性抑郁症（MDD）患者白质的结构特征、纤维完整性及其与抑郁症状的关系。招募2021年9月至2023年5月期间温州市第七人民医院收治的重性抑郁症患者作为实验组，同期招募性别、年龄和受教育年限相匹配的健康志愿者作为对照组。两组在分数各向异性（FA）、平均扩散率（MD）和轴向扩散率（AD）方面进行比较。分析了实验组不同脑区的白质体积、FA 值、MD 值和 AD 值与抑郁症状严重程度之间的关系。实验组包括 58 名患者，对照组包括 60 名健康对照者。在实验组中，右侧额叶下回的白质体积与汉密尔顿抑郁评分量表（HAMD-17）的评分呈负相关（r = -0.355，P < 0.05），左侧顶回与 HAMD-17 的评分呈负相关（r = -0.361，P < 0.05）。白质胼胝体枕放射的 FA 值与 HAMD-17 评分呈负相关（r = -0.410，P <0.05）。此外，左侧和右侧丘脑前部放射白质的 MD 值与 HAMD-17 评分呈负相关（分别为 r = -0.389，P <0.05；r = -0.489，P <0.01），AD 值与 HAMD-17 评分呈负相关（分别为 r = -0.446，-0.405，P <0.05）。MDD 患者的白质体积减少，白质纤维完整性受损，包括顶叶、胼胝体、皮质脊髓束和下纵束。白质结构和纤维完整性的异常与 MDD 的严重程度密切相关。

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来源期刊

Neurochemical Journal 医学-神经科学

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components. The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.