Theranostic Potential of Bacteriophages against Oral Squamous Cell Carcinoma.

IF 3.8 4区 医学 Q2 GENETICS & HEREDITY
Maheswaran Easwaran, Sivagnanavelmurugan Madasamy, Baskar Venkidasamy
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引用次数: 0

Abstract

Oral Squamous Cell Carcinoma (OSCC) is a widespread and challenging disease that accounts for 94% of cancers of the oral cavity worldwide. Bacteriophages (phages) have shown promise as a potential theranostic agent for the treatment of OSCC. It may offer advantages in overcoming the challenges of conventional methods. Modern high-throughput pyrosequencing techniques confirm the presence of specific bacterial strains associated with OSCC. Bio-panning and filamentous phages facilitate visualization of the peptide on surfaces and show high affinity in OSCC cells. The peptide has the potential to bind integrin (αvβ6), aid in diagnosis, and inhibit the proliferation of OSCC cells. Mimotopes of tumor-associated antigens show cytotoxic and immune responses against cancer cells. Biomarker-based approaches such as transferrin enable early OSCC diagnosis. A modified temperate phage introduces CRISPR-Cas3 to target antimicrobial-resistant bacteria associated with OSCC. The research findings highlight the evolving field of phage diagnostics and therapy and represent a new avenue for non-invasive, targeted approaches to the detection and treatment of OSCC. However, extensive clinical research is required to validate the efficacy of phages in innovative cancer theranostic strategies.

噬菌体对口腔鳞状细胞癌的抗癌潜力
口腔鳞状细胞癌(OSCC)是一种广泛存在且具有挑战性的疾病,占全球口腔癌的 94%。细菌噬菌体(噬菌体)有望成为治疗口腔鳞状细胞癌的潜在治疗药物。它在克服传统方法的挑战方面可能具有优势。现代高通量热测序技术证实了与 OSCC 相关的特定细菌菌株的存在。生物平移和丝状噬菌体有助于肽在表面的可视化,并在 OSCC 细胞中显示出很高的亲和力。该多肽具有结合整合素(αvβ6)、帮助诊断和抑制 OSCC 细胞增殖的潜力。肿瘤相关抗原的模拟物能对癌细胞产生细胞毒性和免疫反应。转铁蛋白等基于生物标志物的方法有助于早期诊断 OSCC。一种改良的温带噬菌体引入了CRISPR-Cas3,以针对与OSCC相关的抗微生物细菌。这些研究成果突显了噬菌体诊断和治疗领域的不断发展,为非侵入性、有针对性地检测和治疗 OSCC 提供了一条新途径。然而,要验证噬菌体在创新性癌症治疗策略中的疗效,还需要进行广泛的临床研究。
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来源期刊
Current gene therapy
Current gene therapy 医学-遗传学
CiteScore
6.70
自引率
2.80%
发文量
46
期刊介绍: Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.
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