Physical activity, sedentary behavior, and the risk of functional gastrointestinal disorders: A two-sample Mendelian randomization study

IF 2.3 3区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Journal of Digestive Diseases Pub Date : 2024-05-29 DOI:10.1111/1751-2980.13274

Yan Rui Wu, Zong Biao Tan, Yi Lu, Chuan Liu, Wei Guo Dong

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引用次数: 0

Abstract

Objectives

Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are prevalent functional gastrointestinal disorders (FGIDs). In this study we aimed to explore the causal association between physical activity or sedentary behavior and the risk of FD and IBS.

Methods

Mendelian randomization (MR) analysis was employed. Candidate genetic instruments for physical activity and sedentary behavior were retrieved from the latest published Genome-Wide Association Study (GWAS), which included up to 703 901 participants. Summary-level GWAS data for FD (8 875 cases and 320 387 controls) and IBS (9 323 cases and 301 931 controls) were obtained from the FinnGen study. The causal effects were mainly estimated by inverse variance weighted (IVW) method. Sensitivity analyses were implemented with Cochran's Q test, MR-Egger intercept test, leave-one-out analysis, and the funnel plot.

Results

No significant association of moderate-to-vigorous intensity physical activity (MVPA), leisure screen time (LST), sedentary behavior at work (SDW), and sedentary commuting (SDC) with the risk of FD was found. However, there was a suggestive correlation between MVPA and the decreased risk of FD (odds ratio [OR] 0.63, 95% confidence interval [CI] 0.39–0.99, P = 0.047). Genetically predicted MVPA decreased the risk of IBS (OR 0.58, 95% CI 0.40–0.84, P = 0.004), while increased LST was positively associated with IBS risk (OR 1.33, 95% CI 1.15–1.53, P < 0.001). No causal effects of SDW or SDC on IBS risk were observed.

Conclusion

MVPA and LST are causally linked to the development of IBS, which will facilitate primary prevention of IBS.

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体育锻炼、久坐行为与功能性胃肠病的风险：一项双样本孟德尔随机研究。

目的：功能性消化不良（FD）和肠易激综合征（IBS）是常见的功能性胃肠疾病（FGID）。本研究旨在探讨体力活动或久坐行为与功能性消化不良和肠易激综合征风险之间的因果关系：方法：采用孟德尔随机化（MR）分析。我们从最新发表的全基因组关联研究（GWAS）中检索了体力活动和久坐行为的候选遗传工具，其中包括多达 703901 名参与者。FD（8 875 例病例和 320 387 例对照）和肠易激综合征（9 323 例病例和 301 931 例对照）的汇总级 GWAS 数据来自 FinnGen 研究。因果效应主要采用反方差加权法（IVW）进行估计。敏感性分析采用 Cochran's Q 检验、MR-Egger 截距检验、leave-one-out 分析和漏斗图：结果：中等强度到高强度的体力活动（MVPA）、休闲屏幕时间（LST）、工作时的久坐行为（SDW）和通勤时的久坐行为（SDC）与罹患 FD 的风险无明显关联。然而，MVPA 与罹患 FD 的风险降低之间存在提示性相关性（几率比 [OR] 0.63，95% 置信区间 [CI]0.39-0.99，P = 0.047）。遗传预测的 MVPA 可降低肠易激综合征的风险（OR 0.58，95% CI 0.40-0.84，P = 0.004），而 LST 的增加与肠易激综合征的风险呈正相关（OR 1.33，95% CI 1.15-1.53，P 结论：MVPA 和 LST 与肠易激综合征之间存在因果关系：MVPA 和 LST 与肠易激综合征的发生有因果关系，这将有助于肠易激综合征的一级预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Digestive Diseases 医学-胃肠肝病学

CiteScore

5.40

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Digestive Diseases is the official English-language journal of the Chinese Society of Gastroenterology. The journal is published twelve times per year and includes peer-reviewed original papers, review articles and commentaries concerned with research relating to the esophagus, stomach, small intestine, colon, liver, biliary tract and pancreas.