Epigenetics and environmental health.

IF 3.9 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Frontiers of Medicine Pub Date : 2024-08-01 Epub Date: 2024-05-28 DOI:10.1007/s11684-023-1038-2

Min Zhang, Ting Hu, Tianyu Ma, Wei Huang, Yan Wang

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引用次数: 0

Abstract

Epigenetic modifications including DNA methylation, histone modifications, chromatin remodeling, and RNA modifications complicate gene regulation and heredity and profoundly impact various physiological and pathological processes. In recent years, accumulating evidence indicates that epigenetics is vulnerable to environmental changes and regulates the growth, development, and diseases of individuals by affecting chromatin activity and regulating gene expression. Environmental exposure or induced epigenetic changes can regulate the state of development and lead to developmental disorders, aging, cardiovascular disease, Alzheimer's disease, cancers, and so on. However, epigenetic modifications are reversible. The use of specific epigenetic inhibitors targeting epigenetic changes in response to environmental exposure is useful in disease therapy. Here, we provide an overview of the role of epigenetics in various diseases. Furthermore, we summarize the mechanism of epigenetic alterations induced by different environmental exposures, the influence of different environmental exposures, and the crosstalk between environmental variation epigenetics, and genes that are implicated in the body's health. However, the interaction of multiple factors and epigenetics in regulating the initiation and progression of various diseases complicates clinical treatments. We discuss some commonly used epigenetic drugs targeting epigenetic modifications and methods to prevent or relieve various diseases regulated by environmental exposure and epigenetics through diet.

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表观遗传学与环境健康。

表观遗传修饰（包括 DNA 甲基化、组蛋白修饰、染色质重塑和 RNA 修饰）使基因调控和遗传复杂化，并对各种生理和病理过程产生深远影响。近年来，越来越多的证据表明，表观遗传学易受环境变化的影响，并通过影响染色质活性和调控基因表达来调节个体的生长、发育和疾病。环境暴露或诱导的表观遗传变化可调节发育状态，导致发育障碍、衰老、心血管疾病、阿尔茨海默病、癌症等。然而，表观遗传修饰是可逆的。针对环境暴露引起的表观遗传变化使用特异性表观遗传抑制剂有助于疾病治疗。在此，我们将概述表观遗传学在各种疾病中的作用。此外，我们还总结了不同环境暴露诱导表观遗传学改变的机制、不同环境暴露的影响，以及环境变化表观遗传学与涉及人体健康的基因之间的相互影响。然而，多种因素和表观遗传学在调控各种疾病的发生和发展过程中的相互作用使临床治疗变得复杂。我们将讨论一些针对表观遗传修饰的常用表观遗传药物，以及通过饮食预防或缓解受环境暴露和表观遗传调控的各种疾病的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers of Medicine ONCOLOGYMEDICINE, RESEARCH & EXPERIMENTAL&-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

18.30

自引率

0.00%

发文量

800

期刊介绍： Frontiers of Medicine is an international general medical journal sponsored by the Ministry of Education of China. The journal is jointly published by the Higher Education Press and Springer. Since the first issue of 2010, this journal has been indexed in PubMed/MEDLINE. Frontiers of Medicine is dedicated to publishing original research and review articles on the latest advances in clinical and basic medicine with a focus on epidemiology, traditional Chinese medicine, translational research, healthcare, public health and health policies.