Serum Magnesium Levels Are Negatively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Mellitus: A Real-World Study.

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes & Metabolism Journal Pub Date : 2024-11-01 Epub Date: 2024-05-29 DOI:10.4093/dmj.2023.0401
Man-Rong Xu, Ai-Ping Wang, Yu-Jie Wang, Jun-Xi Lu, Li Shen, Lian-Xi Li
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Abstract

Backgruound: There remains controversy over the relationship between serum magnesium levels and obesity in type 2 diabetes mellitus (T2DM). Therefore, the aim of this study was to assess whether there is any association of serum magnesium levels with obesity and abdominal obesity in T2DM.

Methods: This cross-sectional, real-world study was conducted in 8,010 patients with T2DM, which were stratified into quintiles according to serum magnesium levels. The clinical characteristics and the prevalence of obesity and abdominal obesity were compared across serum magnesium quintiles in T2DM. Regression analyses were used to evaluate the relationship of serum magnesium with obesity and abdominal obesity in T2DM (clinical trial registration number: ChiCTR1800015893).

Results: After adjustment for age, sex, and duration of diabetes, the prevalence of obesity and abdominal obesity was significantly declined across magnesium quintiles (obesity: 51.3%, 50.8%, 48.9%, 45.3%, and 43.8%, respectively, P<0.001 for trend; abdominal obesity: 71.5%, 70.5%, 68.2%, 66.4%, and 64.5%, respectively, P=0.001 for trend). After controlling for confounders, there were clearly negative associations of serum magnesium levels and quintiles with obesity and abdominal obesity in T2DM. Moreover, C-reactive protein partly mediates the effect of serum magnesium on obesity and abdominal obesity (P=0.016 and P=0.004, respectively).

Conclusion: The significantly negative relationship between serum magnesium and the risk of obesity and abdominal obesity was observed in T2DM. Furthermore, the independently negative association of serum magnesium with obesity may be explained by its anti-inflammatory functions. Serum magnesium levels may be applied to assess the risk of obesity and abdominal obesity in T2DM.

血清镁水平与 2 型糖尿病患者的肥胖和腹部肥胖呈负相关:一项真实世界研究
背景:关于 2 型糖尿病(T2DM)患者血清镁水平与肥胖之间的关系仍存在争议。因此,本研究旨在评估血清镁水平与 T2DM 患者肥胖和腹部肥胖是否存在关联:这项横断面真实世界研究的对象是 8010 名 T2DM 患者,根据血清镁水平将其分为五等分。比较了不同血清镁五分位数 T2DM 患者的临床特征以及肥胖和腹型肥胖的患病率。回归分析用于评估血清镁与 T2DM 中肥胖和腹型肥胖的关系(临床试验注册号:ChiCTR1800015893):结果:在对年龄、性别和糖尿病病程进行调整后,不同镁五分位数的肥胖和腹型肥胖发生率显著下降(肥胖:分别为51.3%、50.8%、48.9%、45.3%和43.8%):在 T2DM 患者中观察到血清镁与肥胖和腹型肥胖风险之间存在明显的负相关。此外,血清镁与肥胖的独立负相关关系可能是由于血清镁的抗炎功能。血清镁水平可用于评估 T2DM 患者肥胖和腹型肥胖的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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