Distribution and predictors of F-18-FDG uptake values of non-malignant cervical lymph nodes in pediatric patients.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-05-29 DOI:10.1186/s13550-024-01110-9

Jeremy Godefroy, Raphael Godefroy, Koral Vedder, Yair Altura, Alexandre Chicheportiche, Simona Ben-Haim, Gal Goldstein

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引用次数: 0

Abstract

Background: F-18-flurodeoxyglucose (FDG) PET/CT is routinely used for staging, evaluation of response to treatment and follow-up of most pediatric malignancies. Cervical lymph nodes can be involved in some pediatric malignancies, but increased uptake in non-malignant cervical lymph nodes is not exceptional in this population. The aim of the present study is to identify predictors of the maximum uptake in non-malignant cervical lymph nodes in the pediatric population.

Methods: 191 FDG PET/CT studies of pediatric patients without malignant involvement of cervical lymph nodes were retrospectively reviewed. The maximal Standard Uptake Value in the hottest cervical lymph node (SUVmax_CLN), as well as demographic, technical and imaging variables were recorded. The predictive effect of those variables on SUVmax_CLN was estimated using linear regression models.

Results: Increased FDG activity in cervical nodes was observed in 136/191 studies (71%). The mean SUVmax_CLN was 2.2 ± 1.3. Ipsilateral palatine tonsil SUVmax, mean liver uptake, and treatment status were all statistically significant predictors of SUVmax_CLN. However, in multivariate regression analysis, only ipsilateral palatine tonsil SUVmax was found to be significant. In addition, SUVmax_CLN was greater than the mean liver uptake in 50% of all studies. This proportion was higher in younger children, reaching 77% of studies of children younger than six years.

Conclusion: SUVmax in ipsilateral palatine tonsil is a strong predictor of the maximal uptake value of non-malignant cervical lymph nodes in children. The intensity of uptake in non-malignant cervical lymph nodes is frequently higher than liver uptake in children, and this tendency increases for younger patients.

Trial was registered: In the internal hospital registry under TRN 0209-22-HMO on date 23.04.2022.

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儿科非恶性颈淋巴结 F-18-FDG 摄取值的分布和预测因素。

背景：F-18-氟脱氧葡萄糖（FDG）正电子发射计算机断层扫描（PET/CT）被常规用于大多数儿科恶性肿瘤的分期、治疗反应评估和随访。某些儿科恶性肿瘤可能累及颈淋巴结，但非恶性颈淋巴结摄取增加在这一人群中并不罕见。本研究旨在确定儿科非恶性颈淋巴结最大摄取值的预测因素。方法：对191例未恶性累及颈淋巴结的儿科患者的FDG PET/CT研究进行了回顾性回顾。记录了最热颈部淋巴结的最大标准摄取值（SUVmaxCLN）以及人口统计学、技术和成像变量。利用线性回归模型估算了这些变量对 SUVmaxCLN 的预测作用：结果：136/191 项研究（71%）观察到宫颈结节中 FDG 活性增加。平均 SUVmaxCLN 为 2.2 ± 1.3。同侧腭扁桃体SUVmax、肝脏平均摄取量和治疗状态都是SUVmaxCLN的统计学显著预测因素。然而，在多变量回归分析中，只有同侧腭扁桃体 SUVmax 具有显著性。此外，在所有研究中，50% 的研究发现 SUVmaxCLN 大于肝脏平均摄取量。这一比例在年龄较小的儿童中更高，在对 6 岁以下儿童的研究中达到 77%：结论：同侧腭扁桃体的 SUVmax 是预测儿童非恶性颈淋巴结最大摄取值的有力指标。在儿童中，非恶性颈淋巴结的摄取强度往往高于肝脏摄取，而且这种趋势在年龄较小的患者中会加剧：医院内部登记：TRN 0209-22-HMO，日期为 2022 年 4 月 23 日。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567