Research progress and application of liver organoids for disease modeling and regenerative therapy.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI:10.1007/s00109-024-02455-3

Yang Hu, Qiao Geng, Lu Wang, Yi Wang, Chuyue Huang, Zhimin Fan, Desong Kong

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Abstract

The liver is a major metabolic organ of the human body and has a high incidence of diseases. In recent years, the annual incidence of liver disease has increased, seriously endangering human life and health. The study of the occurrence and development mechanism of liver diseases, discovery of new therapeutic targets, and establishment of new methods of medical treatment are major issues related to the national economy and people's livelihood. The development of stable and effective research models is expected to provide new insights into the pathogenesis of liver diseases and the search for more effective treatment options. Organoid technology is a new in vitro culture system, and organoids constructed by human cells can simulate the morphological structure, gene expression, and glucose and lipid metabolism of organs in vivo, providing a new model for related research on liver diseases. This paper reviews the latest research progress on liver organoids from the establishment of cell sources and application of liver organoids and discusses their application potential in the field of liver disease research.

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肝脏器官组织用于疾病建模和再生治疗的研究进展和应用。

肝脏是人体的主要代谢器官，也是疾病的高发区。近年来，肝病的发病率逐年上升，严重危害着人类的生命健康。研究肝脏疾病的发生、发展机制，发现新的治疗靶点，建立新的医疗方法，是关系到国计民生的重大问题。建立稳定、有效的研究模型，有望为了解肝脏疾病的发病机理、寻找更有效的治疗方案提供新的视角。类器官技术是一种新的体外培养体系，由人体细胞构建的类器官可以模拟体内器官的形态结构、基因表达、糖脂代谢等，为肝脏疾病的相关研究提供了新的模型。本文从细胞来源的建立、肝脏器官组织的应用等方面综述了肝脏器官组织的最新研究进展，并探讨了其在肝脏疾病研究领域的应用潜力。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.