Effectiveness and Safety of Carbon Ion Radiotherapy in Solid Tumors: A Systematic Review and Meta-Analysis.

IF 2.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Yonsei Medical Journal Pub Date : 2024-06-01 DOI:10.3349/ymj.2023.0439

Ji Eun Yun, Sujin Kim, Keun Young Park, Worlsook Lee

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引用次数: 0

Abstract

Purpose: This systematic review and meta-analysis aimed to investigate the effectiveness of carbon ion radiotherapy (CIRT) compared to that of conventional radiotherapy in patients with various types of solid tumors.

Materials and methods: We systematically searched eight electronic databases from inception until August 2022 in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The comparative effectiveness of the different treatment options was assessed by a random-effects meta-analysis.

Results: This review included 34 comparative studies and three treatment groups. Overall, the meta-analysis indicated comparable local control rates between the CIRT and control groups [pooled risk ratio (RR)=1.02, 95% confidence interval (CI) 0.90-1.15]. The local control rate in the CIRT group was higher than that in the photon therapy group, but slightly lower than that in the proton radiation therpy (PRT) group. Additionally, the CIRT group had significantly higher overall survival (OS) (RR=1.19, 95% CI=1.01-1.42) and progression-free survival (PFS) (RR=1.50, 95% CI=1.01-2.21) rates compared to the control group. In the subgroup analysis, survival rates were similar between the CIRT and PRT groups.

Conclusion: CIRT was associated with improved toxicity, local tumor control, OS, and PFS compared to conventional treatments. Therefore, CIRT was found to be a safe and effective option for achieving local control in patients with solid tumors.

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实体瘤碳离子放疗的有效性和安全性：系统回顾与元分析》。

目的：本系统综述和荟萃分析旨在研究碳离子放疗（CIRT）与传统放疗相比对各类实体瘤患者的有效性：根据《系统综述和荟萃分析首选报告项目》指南，我们系统检索了从开始到2022年8月的8个电子数据库。通过随机效应荟萃分析评估了不同治疗方案的比较效果：本综述包括 34 项比较研究和三个治疗组。总体而言，荟萃分析表明 CIRT 组和对照组的局部控制率相当[汇总风险比 (RR)=1.02, 95% 置信区间 (CI) 0.90-1.15]。CIRT 组的局部控制率高于光子治疗组，但略低于质子放射治疗（PRT）组。此外，与对照组相比，CIRT 组的总生存率（OS）（RR=1.19，95% CI=1.01-1.42）和无进展生存率（PFS）（RR=1.50，95% CI=1.01-2.21）明显更高。在亚组分析中，CIRT组与PRT组的生存率相似：结论：与传统疗法相比，CIRT可改善毒性、局部肿瘤控制、OS和PFS。因此，CIRT 是实体瘤患者实现局部控制的一种安全有效的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Yonsei Medical Journal 医学-医学：内科

CiteScore

4.50

自引率

0.00%

发文量

167

审稿时长

3 months

期刊介绍： The goal of the Yonsei Medical Journal (YMJ) is to publish high quality manuscripts dedicated to clinical or basic research. Any authors affiliated with an accredited biomedical institution may submit manuscripts of original articles, review articles, case reports, brief communications, and letters to the Editor.