Insulin Requirements According to Sex and Weight in a Population of 9036 Adult Persons With Type 1 Diabetes Using Closed-Loop Insulin Delivery.

IF 3.7 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Science and Technology Pub Date : 2025-09-01 Epub Date: 2024-05-28 DOI:10.1177/19322968241252366

Hocine Lebbad, Chesner Desir, Aurélien Vesin, Alice Adenis, Guillaume Charpentier, Pierre-Yves Benhamou

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Abstract

Background: The prediction of the individual insulin needs may facilitate the initiation of insulin therapy. Our aim was to explore the relationships between body weight, sex, and daily amounts of insulin delivered by a hybrid closed-loop system.

Methods: We performed a retrospective data collection of all consenting adult patients with type 1 diabetes who were equipped in Europe with the Diabeloop Generation 1 (DBLG1) hybrid closed-loop insulin delivery device between March 1, 2021 and February 28, 2023.

Results: A total of 9036 users (59% females, age 45.6 ± 14.3 years) were included, reaching a mean follow-up of 320 ± 143 days, an overall 2 887 188 days of data. We observed a mean insulin-weight ratio of 0.617 ± 0.207 U/kg (0.665 ± 0.217 for males and 0.584 ± 0.193 for females, P < .001). Exploratory analysis of a subset of 4066 patients reaching >70% Time in Range (70-180 mg/dL) showed a mean insulin-weight ratio of 0.55 ± 0.17 U/kg (P < .001) (0.59 ± 0.18 for the 1438 males and 0.53 ± 0.16 for the 2628 females).

Conclusion: This large real-world analysis provides a quantitative estimation of the daily insulin requirements in adult patients with type 1 diabetes and shows significant differences between sex. These findings have relevant implications in the practical management of insulin therapy.

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使用闭环胰岛素输送系统的 9036 名 1 型糖尿病成年患者根据性别和体重的胰岛素需求量。

背景：预测个人的胰岛素需求有助于胰岛素治疗的启动。我们的目的是探索体重、性别与混合闭环系统每日胰岛素用量之间的关系：我们对 2021 年 3 月 1 日至 2023 年 2 月 28 日期间在欧洲安装了 Diabeloop 第一代（DBLG1）混合闭环胰岛素输送装置的所有征得同意的 1 型糖尿病成年患者进行了回顾性数据收集：共纳入 9036 名用户（59% 为女性，年龄为 45.6 ± 14.3 岁），平均随访时间为 320 ± 143 天，总数据量为 2 887 188 天。我们观察到平均胰岛素体重比为 0.617 ± 0.207 U/kg（男性为 0.665 ± 0.217，女性为 0.584 ± 0.193，P < .001）。对胰岛素在量程（70-180 mg/dL）内达到 >70% 时间的 4066 例患者进行的探索性分析显示，平均胰岛素重量比为 0.55 ± 0.17 U/kg（P < .001）（1438 例男性为 0.59 ± 0.18，2628 例女性为 0.53 ± 0.16）：这项大型真实世界分析提供了对成年 1 型糖尿病患者每日胰岛素需求量的定量估计，并显示出性别间的显著差异。这些发现对胰岛素治疗的实际管理具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Science and Technology Medicine-Internal Medicine

CiteScore

7.50

自引率

12.00%

发文量

148

期刊介绍： The Journal of Diabetes Science and Technology (JDST) is a bi-monthly, peer-reviewed scientific journal published by the Diabetes Technology Society. JDST covers scientific and clinical aspects of diabetes technology including glucose monitoring, insulin and metabolic peptide delivery, the artificial pancreas, digital health, precision medicine, social media, cybersecurity, software for modeling, physiologic monitoring, technology for managing obesity, and diagnostic tests of glycation. The journal also covers the development and use of mobile applications and wireless communication, as well as bioengineered tools such as MEMS, new biomaterials, and nanotechnology to develop new sensors. Articles in JDST cover both basic research and clinical applications of technologies being developed to help people with diabetes.