Association of disease duration and PASI response rates at week 12 in patients with moderate-to-severe plaque psoriasis receiving biologics in the real-world psoriasis study of health outcomes (PSoHO).

Andreas Pinter, Kilian Eyerich, Antonio Costanzo, Alyssa Garrelts, Christopher Schuster, Can Mert, Anastasia Lampropoulou, Konstantinos Fotiou, Julia-Tatjana Maul, Kim A Papp
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Abstract

Purpose: Currently, in the treatment of moderate-to-severe psoriasis (PsO) there is a lack of evidence demonstrating optimal biologic treatment response with respect to disease duration. The aim of this post-hoc analysis, using real world data from the Psoriasis Study of Health Outcomes (PSoHO), is to provide evidence if early intervention with biologics is associated with better treatment outcomes and if there is any difference among drug classes or individual biologics.

Materials and methods: For this post-hoc analysis patients were categorised into two subgroups according to shorter (≤2 years) or longer (>2 years) disease duration. Analysis was performed on anti-interleukin (IL)-17A cohort vs other biologics cohort, anti-IL-17A vs other drug classes, and pairwise comparisons of ixekizumab vs individual biologics, provided that the statistical models converged. Analysis investigated the association of disease duration with the proportion of patients achieving 100% improvement in Psoriasis Area Severity Index score (PASI 100) at week 12. Adjusted comparative analyses, reported as odds ratio (OR), were performed using Frequentist Model Averaging (FMA) for each cohort or treatments within each subcategory of the subgroups.

Results: At week 12, anti-IL-17A and other biologics cohorts displayed minimal differences in numerical response rate for PASI 100 with respect to disease duration. The anti-IL-17A cohort showed a higher numerical PASI 100 response rate compared to the other biologic cohort irrespective of disease duration (≤2 years: 36.7% vs 21.8%; >2 years: 35.8% vs 21.9%).

Conclusion: Overall, the results do not clearly indicate that treating patients early is critical in achieving optimal patient outcomes. Furthermore, patients treated with ixekizumab show numerically higher response rates relative to other individual biologics irrespective of disease duration.

在真实世界银屑病健康结果研究(PSoHO)中,接受生物制剂治疗的中重度斑块状银屑病患者的病程与第 12 周 PASI 反应率之间的关系。
目的:目前,在中度至重度银屑病(PsO)的治疗中,缺乏证据表明生物制剂治疗对病程的最佳反应。这项事后分析的目的是利用银屑病健康结果研究(PSoHO)的真实数据,证明生物制剂的早期干预是否与更好的治疗效果相关,以及药物类别或单个生物制剂之间是否存在差异:在这项事后分析中,根据病程较短(≤2 年)或较长(>2 年)将患者分为两个亚组。在统计模型趋同的前提下,对抗白细胞介素(IL)-17A组与其他生物制剂组、抗IL-17A组与其他药物组以及ixekizumab与单个生物制剂的配对比较进行了分析。分析调查了疾病持续时间与第12周时银屑病面积严重程度指数(PASI 100)100%改善的患者比例之间的关系。使用频数模型平均法(FMA)对每个组群或亚组中每个亚类的治疗方法进行调整比较分析,以几率比(OR)报告:第 12 周时,抗-IL-17A 和其他生物制剂组在 PASI 100 数值反应率方面与病程的差异极小。抗IL-17A组与其他生物制剂组相比,无论病程长短,PASI 100数值应答率都更高(≤2年:36.7% vs 21.8%;>2年:35.8% vs 21.9%):总体而言,研究结果并没有明确表明早期治疗对患者获得最佳疗效至关重要。此外,无论病程长短,接受ixekizumab治疗的患者的反应率在数字上都高于接受其他生物制剂治疗的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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