Simultaneous assessment of blood flow and myelin content in the brain white matter with dynamic [11 C]PiB PET: a test-retest study in healthy controls.

IF 3.1 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

EJNMMI Research Pub Date : 2024-05-27 DOI:10.1186/s13550-024-01107-4

Arya Yazdan-Panah, Benedetta Bodini, Théodore Soulier, Mattia Veronese, Michel Bottlaender, Matteo Tonietto, Bruno Stankoff

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引用次数: 0

Abstract

Background: Exploring the relationship between oxygen supply and myelin damage would benefit from a simultaneous quantification of myelin and cerebral blood flow (CBF) in the brain's white matter (WM). To validate an analytical method for quantifying both CBF and myelin content in the WM using dynamic [¹¹C]PiB positron emission tomography (PET).

Methods: A test-retest study was performed on eight healthy subjects who underwent two consecutive dynamic [11 C]PiB-PET scans. Three quantitative approaches were compared: simplified reference tissue model 2 (SRTM2), LOGAN graphical model, and standardized uptake value ratio (SUVR). The sensitivity of methods to the size of the region of interest was explored by simulating lesion masks obtained from 36 subjects with multiple sclerosis. Reproducibility was assessed using the relative difference and interclass correlation coefficient. Repeated measures correlations were used to test for cross-correlations between metrics.

Results: Among the CBF measures, the relative delivery (R1) of the simplified reference tissue model 2 (SRTM2) displayed the best reproducibility in the white matter, with a strong influence of the size of regions analyzed, the test-retest variability being below 10% for regions above 68 mm³ in the supratentorial white matter. [¹¹C]PiB PET-derived proxies of CBF demonstrated lower perfusion of white matter compared to grey matter with an overall ratio equal to 1.71 ± 0.09 when the SRTM2-R1 was employed. Tissue binding in the white matter was well estimated by the Logan graphical model through estimation of the distribution volume ratio (LOGAN-DVR) and SRTM2 distribution volume ratio (SRTM2-DVR), with test-retest variability being below 10% for regions exceeding 106 mm³ for LOGAN-DVR and 300 mm³ for SRTM2-DVR. SRTM2-DVR provided a better contrast between white matter and grey matter. The interhemispheric variability was also dependent on the size of the region analyzed, being below 10% for regions above 103 mm³ for SRTM2-R1 and above 110 mm³ for LOGAN-DVR. Whereas the 1 to 8-minute standardized uptake value ratio (SUVR1-8) showed an intermediary reproducibility for CBF assessment, SUVR0-2 for perfusion or SUVR50-70 for tissue binding showed poor reproducibility and correlated only mildly with SRTM2-R1 and LOGAN-DVR estimations respectively.

Conclusions: [¹¹C]PiB PET imaging can simultaneously quantify perfusion and myelin content in WM diseases associated with focal lesions. For longitudinal studies, SRTM2-R1 and DVR should be preferred over SUVR for the assessment of regional CBF and myelin content, respectively.

Trial registration: European Union Clinical Trials Register EUDRACT; EudraCT Number: 2008-004174-40; Date: 2009-03-06; https//www.clinicaltrialsregister.eu ; number 2008-004174-40.

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利用动态[11 C]PiB PET 同时评估脑白质中的血流量和髓鞘含量：对健康对照组的测试-再测试研究。

背景：同时量化大脑白质（WM）中的髓鞘和脑血流（CBF）将有助于探索供氧和髓鞘损伤之间的关系。目的是验证一种利用动态[11C]PiB 正电子发射断层扫描（PET）同时量化脑白质中 CBF 和髓鞘含量的分析方法：方法：对连续接受两次动态[11C]PiB-PET 扫描的八名健康受试者进行了重复测试研究。比较了三种定量方法：简化参考组织模型 2（SRTM2）、LOGAN 图形模型和标准化摄取值比（SUVR）。通过模拟从 36 名多发性硬化症患者身上获得的病灶掩膜，探讨了各种方法对感兴趣区大小的敏感性。使用相对差异和类间相关系数评估了再现性。重复测量相关性用于检验指标之间的交叉相关性：结果：在CBF测量指标中，简化参考组织模型2（SRTM2）的相对输送量（R1）在白质中显示出最好的重现性，分析区域的大小对其影响很大，在幕上白质中，68立方毫米以上区域的测试-重测变异性低于10%。当使用 SRTM2-R1 时，[11C]PiB PET 衍生的 CBF 代用指标显示白质的灌注量低于灰质，总比率等于 1.71 ± 0.09。洛根图形模型通过估计分布容积比（LOGAN-DVR）和 SRTM2 分布容积比（SRTM2-DVR）很好地估计了白质中的组织结合力，对于超过 106 立方毫米的区域（LOGAN-DVR）和超过 300 立方毫米的区域（SRTM2-DVR），测试-重复变异性低于 10%。SRTM2-DVR 在白质和灰质之间提供了更好的对比。半球间的可变性也取决于分析区域的大小，SRTM2-R1 的分析区域超过 103 立方毫米时，半球间的可变性低于 10%；LOGAN-DVR 的分析区域超过 110 立方毫米时，半球间的可变性低于 10%。1-8分钟标准化摄取值比值（SUVR1-8）在CBF评估中显示出中等水平的可重复性，而灌注的SUVR0-2或组织结合的SUVR50-70显示出很差的可重复性，分别与SRTM2-R1和LOGAN-DVR估计值只有轻微的相关性：结论：[11C]PiB PET 成像可同时量化与局灶性病变相关的 WM 疾病中的灌注和髓鞘含量。结论：[11C]PiB PET 成像可同时量化 WM 疾病中与局灶性病变相关的灌注和髓鞘含量。对于纵向研究，SRTM2-R1 和 DVR 分别比 SUVR 更适合用于评估区域 CBF 和髓鞘含量：试验注册：欧盟临床试验注册中心EUDRACT；EudraCT编号：2008-004174-40；日期：2009-03-06；https//www.clinicaltrialsregister.eu；编号2008-004174-40。

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来源期刊

EJNMMI Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING&nb-

CiteScore

5.90

自引率

3.10%

发文量

审稿时长

13 weeks

期刊介绍： EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies. The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy.