Synthesis and Anti-inflammatory, Analgesic, and Antipyretic Activities of Azomethine Derivatives of the Tetrahydropyran Series

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2024-05-19 DOI:10.1134/s1070428024030230

A. U. Isakhanyan, N. Z. Hakobyan, R. E. Muradyan, H. E. Tumajyan, H. A. Panosyan, A. A. Harutyunyan

引用次数: 0

Abstract

Schiff bases of the tetrahydropyran series have been synthesized by the condensation of 2-(tetrahydropyran-4-yl)ethanamines and tetrahydropyran-4-amine with 4-chloro, 4-fluoro-, and 4-(dimethylamino)benzaldehydes and thiophene-2-carbaldehyde. The synthesized compounds showed lower anti-inflammatory, analgesic, and antipyretic activities than those of diclofenac and indomethacin used as reference drugs.

查看原文本刊更多论文

四氢吡喃系列偶氮甲烷衍生物的合成及其抗炎、镇痛和解热活性

摘要通过 2-(四氢吡喃-4-基)乙胺和四氢吡喃-4-胺与 4-氯、4-氟和 4-(二甲基氨基)苯甲醛以及噻吩-2-甲醛的缩合，合成了四氢吡喃系列的希夫碱。合成化合物的抗炎、镇痛和解热活性低于作为参考药物的双氯芬酸和吲哚美辛。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.

文献相关原料

公司名称	产品信息	采购帮参考价格