Ciliary Neurotrophic Factor (CNTF), a Pleiotropic Cytokine: Potential Biomarker of Brain Diseases?

IF 0.5 4区医学 Q4 NEUROSCIENCES

Neurochemical Journal Pub Date : 2024-05-24 DOI:10.1134/s181971242401029x

A. A. Gudkova

引用次数: 0

Abstract

Ciliary neurotrophic factor (CNTF) is a pluripotent neurotrophic factor with a high neuroprotective potential, a neurocytokine that has shown potential in therapy of neurodegenerative, mental and metabolic diseases. Pre-clinical data support the general concept of its promising survival and trophic effects, while recent clinical data support the theoretical role of CNTF for treating neurodegeneration and obesity. The data of occasional studies on CNTF levels in invasive (blood) and non-invasive (tears) human biomaterial suggest its potential use as a biomarker of selected brain diseases, though additional studies should be performed to validate it.

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睫状神经营养因子 (CNTF)，一种多效细胞因子：脑疾病的潜在生物标志物？

摘要睫状神经营养因子（CNTF）是一种具有高度神经保护潜力的多能神经营养因子，是一种在治疗神经退行性疾病、精神疾病和代谢性疾病方面具有潜力的神经细胞因子。临床前数据支持 CNTF 具有生存和营养作用的一般概念，而最近的临床数据则支持 CNTF 在治疗神经变性和肥胖症方面的理论作用。对侵入性（血液）和非侵入性（眼泪）人体生物材料中 CNTF 水平的不定期研究数据表明，CNTF 有可能被用作某些脑部疾病的生物标志物，但还需要进行更多的研究来验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurochemical Journal 医学-神经科学

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components. The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.