Green synthesis of silver nanoparticles using leaf extract of Woodfordia fruticosa (L.) for potential therapeutic application

IF 2.8 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of chemical technology and biotechnology Pub Date : 2024-05-22 DOI:10.1002/jctb.7681

Debasmita Dubey, Rajesh Kumar Meher, Biswaranjan Pradhan, Sadhni Induar, Biswakanth Kar, Pradeep Kumar Naik, Bikash Chandra Behera

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引用次数: 0

Abstract

BACKGROUND

Woodfordia fruticosa is a well-known medicinal plant traditionally used for various treatment methods. Green synthesis of silver nanocomposite with woodfordia flower extract is well-investigated. However, the therapeutic potential of Woodfordia fruticosa leaf extract silver nanoparticles against various diseases has yet to be investigated.

RESULTS

Silver nanoparticles synthesized from Woodfordia fruticosa leaf extract (Wf-AgNPs) showed UV spectral peaks at 450 nm. Transmission electron microscope (TEM) images, ranging from 20 to 50 nm, confirm the nanosynthesis. The average particle size of 39.63 nm with a zeta potential distribution value 17.0 was observed. Fourier transform infrared peaks ranging from 2942to 669 cm⁻¹ confirm the amines, amides, carboxylic, aldehyde, alkane, phenolic and aliphatic bromo compounds involved in the synthesis of AgNPs. Wf-AgNPs showed higher antioxidant activity compared to the ascorbic acid and BHT. The phenolic and flavonoid content was 141.66 ± 8.50 mg GAE/100 g dry weight and 191.66 ± 5.6 mg quercetin equivalent/100 g dry weight, respectively. Wf-AgNPs showed a strong inverse relationship between the dose and viability of the cancer cells. The antibacterial properties of Wf-AgNPs were confirmed through the bacteria's SEM images. Increased wound healing potential, re-epithelization and elevation of the tensile strength of the infected skin tissue were observed after applying synthesized Wf-AgNPs.

CONCLUSION

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利用木芙蓉（L.）叶提取物绿色合成银纳米粒子的潜在治疗应用

背景木芙蓉是一种著名的药用植物，传统上用于各种治疗方法。用木芙蓉花提取物绿色合成银纳米复合材料的研究进展顺利。结果用木芙蓉叶提取物合成的纳米银颗粒（Wf-AgNPs）在 450 纳米波长处显示出紫外光谱峰。透射电子显微镜（TEM）图像在 20 至 50 纳米之间，证实了纳米合成。观察到平均粒径为 39.63 nm，zeta 电位分布值为 17.0。从 2942 到 669 cm-1 的傅立叶变换红外峰值证实，胺、酰胺、羧酸、醛、烷、酚和脂肪族溴化合物参与了 AgNPs 的合成。与抗坏血酸和 BHT 相比，Wf-AgNPs 表现出更高的抗氧化活性。酚类和类黄酮含量分别为 141.66 ± 8.50 毫克 GAE/100 克干重和 191.66 ± 5.6 毫克槲皮素当量/100 克干重。Wf-AgNPs 的剂量与癌细胞的存活率之间呈强烈的反比关系。细菌的扫描电镜图像证实了 Wf-AgNPs 的抗菌特性。结论合成纳米粒子中的各种植物化学物质赋予了 Wf-AgNPs 抗菌、抗氧化、抗癌和伤口愈合的潜力。© 2024 化学工业学会（SCI）。

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来源期刊

Journal of chemical technology and biotechnology 工程技术-工程：化工

CiteScore

7.00

自引率

5.90%

发文量

268

审稿时长

1.7 months

期刊介绍： Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.