Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune Homeostasis

IF 3.6 3区医学

Clinical Interventions in Aging Pub Date : 2024-05-23 DOI:10.2147/cia.s463297

Cunzi Li, Lan Zhou, Hongyan Sun, Ming Ming Yang

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引用次数: 0

Abstract

Abstract: Age-related macular degeneration (AMD) is a degenerative ocular disease primarily affecting central vision in the elderly. Its pathogenesis is complex, involving cellular senescence and immune homeostasis dysregulation. This review investigates the interaction between these two critical biological processes in AMD pathogenesis and their impact on disease progression. Initially, cellular senescence is analyzed, with particular emphasis on retinal damage induced by senescent retinal pigment epithelial cells. Subsequently, the occurrence of immune homeostasis dysregulation within the retina and its mechanistic role in AMD areis explored. Furthermore, the paper also discusses in detail the interplay between cellular senescence and immune responses, forming a vicious cycle that exacerbates retinal damage and may influence treatment outcomes. In summary, a deeper understanding of the interrelation between cellular senescence and immune dysregulation is vital for the developing innovative therapeutic strategies for AMD.

Keywords: age-related macular degeneration, cellular senescence, immune homeostasis dysregulation

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老年性黄斑变性：一种细胞衰老和免疫平衡失调的疾病

摘要：老年性黄斑变性（AMD）是一种退行性眼病，主要影响老年人的中心视力。其发病机制十分复杂，涉及细胞衰老和免疫平衡失调。本综述探讨了这两个关键生物过程在 AMD 发病机制中的相互作用及其对疾病进展的影响。首先分析细胞衰老，特别强调衰老的视网膜色素上皮细胞诱发的视网膜损伤。随后，探讨了视网膜内免疫平衡失调的发生及其在老年性视网膜病变中的机理作用。此外，本文还详细讨论了细胞衰老与免疫反应之间的相互作用，这种相互作用形成了一个恶性循环，加剧了视网膜损伤，并可能影响治疗效果。总之，深入了解细胞衰老和免疫失调之间的相互关系对于开发治疗AMD的创新策略至关重要。关键词：老年性黄斑变性；细胞衰老；免疫平衡失调

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.