Effect of Classic Ketogenic Diet Versus Modified Atkins Diet over Electro-Encephalogram Findings in Children with Refractory Epilepsy

Q4 Medicine

Medical Journal of Dr. D.Y. Patil Vidyapeeth Pub Date : 2024-05-01 DOI:10.4103/mjdrdypu.mjdrdypu_726_23

Vaishali Deshpande, Purnima Prabhu, V. Udani, S. Agarkhedkar

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Abstract

ABSTRACT Ketogenic diet (KD) is well known for control of refractory epilepsy. We wanted to study the effect of the two types of diets: classic KD and modified Atkins diet (MAD) with Indian foods to children of refractory epilepsy on electroencephalogram (EEG). To determine the effect of KD on EEG on children with refractory epilepsy. Ethics Committee approval was taken for randomized controlled trials. Sixty-five children of refractory epilepsy of 6 months to 12 years’ age from two tertiary care teaching institutes, of Pune and Mumbai, were selected and allocated to one of the two types of diets, classic KD and MAD, and followed over a period of 6 months. EEG was done in the beginning, at 3 months, and at 6 months of completion of therapy with standard techniques. The relationship of EEG findings at 3 months follow-up was statistically non-significant, but at the end of 6 months, when overall improved activity on EEG was compared, it had a significant difference of P-value = 0.01, stating KD better than MAD. Classic KD is better than MAD.

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经典生酮饮食与改良阿特金斯饮食对难治性癫痫儿童脑电图结果的影响

摘要众所周知，生酮饮食（KD）可控制难治性癫痫。我们希望研究两种饮食对难治性癫痫患儿脑电图（EEG）的影响：经典生酮饮食（KD）和添加印度食品的改良阿特金斯饮食（MAD）。确定 KD 对难治性癫痫患儿脑电图的影响。随机对照试验已获得伦理委员会批准。从普纳和孟买的两所三级医疗教学机构中挑选了 65 名 6 个月至 12 岁的难治性癫痫患儿，将他们分配到两种饮食（经典 KD 和 MAD）中的一种，并进行为期 6 个月的跟踪观察。在开始治疗、治疗 3 个月和完成治疗 6 个月时，均采用标准技术进行脑电图检查。在 3 个月的随访中，脑电图结果之间的关系在统计学上并不显著，但在 6 个月结束时，当比较脑电图上总体改善的活动时，P 值=0.01，差异显著，说明 KD 优于 MAD。经典的 KD 优于 MAD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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