FGF21 as a mediator of adaptive changes in food intake and macronutrient preference in response to protein restriction

IF 4.6 2区医学 Q1 NEUROSCIENCES

Neuropharmacology Pub Date : 2024-05-24 DOI:10.1016/j.neuropharm.2024.110010

Sora Q. Kim , Redin A. Spann , Md Shahjalal H. Khan , Hans-Rudolf Berthoud , Heike Münzberg , Vance L. Albaugh , Yanlin He , David H. McDougal , Paul Soto , Sangho Yu , Christopher D. Morrison

{"title":"FGF21 as a mediator of adaptive changes in food intake and macronutrient preference in response to protein restriction","authors":"Sora Q. Kim , Redin A. Spann , Md Shahjalal H. Khan , Hans-Rudolf Berthoud , Heike Münzberg , Vance L. Albaugh , Yanlin He , David H. McDougal , Paul Soto , Sangho Yu , Christopher D. Morrison","doi":"10.1016/j.neuropharm.2024.110010","DOIUrl":null,"url":null,"abstract":"<div><p>Free-feeding animals navigate complex nutritional landscapes in which food availability, cost, and nutritional value can vary markedly. Animals have thus developed neural mechanisms that enable the detection of nutrient restriction, and these mechanisms engage adaptive physiological and behavioral responses that limit or reverse this nutrient restriction. This review focuses specifically on dietary protein as an essential and independently defended nutrient. Adequate protein intake is required for life, and ample evidence exists to support an active defense of protein that involves behavioral changes in food intake, food preference, and food motivation, likely mediated by neural changes that increase the reward value of protein foods. Available evidence also suggests that the circulating hormone fibroblast growth factor 21 (FGF21) acts in the brain to coordinate these adaptive changes in food intake, making it a unique endocrine signal that drives changes in macronutrient preference in the context of protein restriction.</p><p>This article is part of the Special Issue on \"Food intake and feeding states\".</p></div>","PeriodicalId":19139,"journal":{"name":"Neuropharmacology","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropharmacology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0028390824001795","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Free-feeding animals navigate complex nutritional landscapes in which food availability, cost, and nutritional value can vary markedly. Animals have thus developed neural mechanisms that enable the detection of nutrient restriction, and these mechanisms engage adaptive physiological and behavioral responses that limit or reverse this nutrient restriction. This review focuses specifically on dietary protein as an essential and independently defended nutrient. Adequate protein intake is required for life, and ample evidence exists to support an active defense of protein that involves behavioral changes in food intake, food preference, and food motivation, likely mediated by neural changes that increase the reward value of protein foods. Available evidence also suggests that the circulating hormone fibroblast growth factor 21 (FGF21) acts in the brain to coordinate these adaptive changes in food intake, making it a unique endocrine signal that drives changes in macronutrient preference in the context of protein restriction.

This article is part of the Special Issue on "Food intake and feeding states".

查看原文本刊更多论文

FGF21 是蛋白质限制导致食物摄入量和宏量营养素偏好发生适应性变化的介质

自由进食的动物在复杂的营养环境中穿梭，食物的可获得性、成本和营养价值可能会有明显的差异。因此，动物发展出了能够检测营养限制的神经机制，这些机制会产生适应性生理和行为反应，从而限制或逆转营养限制。本综述特别关注作为必需营养素和独立防御营养素的膳食蛋白质。生命需要摄入充足的蛋白质，大量证据支持对蛋白质的主动防御，包括食物摄入、食物偏好和食物动机的行为变化，这可能是由增加蛋白质食物奖励价值的神经变化介导的。现有证据还表明，循环中的荷尔蒙成纤维细胞生长因子 21（FGF21）在大脑中起着协调这些食物摄入量适应性变化的作用，使其成为一种独特的内分泌信号，在限制蛋白质摄入的情况下驱动宏量营养素偏好的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neuropharmacology 医学-神经科学

CiteScore

10.00

自引率

4.30%

发文量

288

审稿时长

45 days

期刊介绍： Neuropharmacology publishes high quality, original research and review articles within the discipline of neuroscience, especially articles with a neuropharmacological component. However, papers within any area of neuroscience will be considered. The journal does not usually accept clinical research, although preclinical neuropharmacological studies in humans may be considered. The journal only considers submissions in which the chemical structures and compositions of experimental agents are readily available in the literature or disclosed by the authors in the submitted manuscript. Only in exceptional circumstances will natural products be considered, and then only if the preparation is well defined by scientific means. Neuropharmacology publishes articles of any length (original research and reviews).