Formulation and Evaluation of Ethosomal Cream containing Resveratrol for the Treatment of Contact Dermatitis

Nidhika Kaundal, Pravin Kumar
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Abstract

Objective: The aim of this study was to formulate and evaluate ethosomal cream containing resveratrol for the treatment of contact dermatitis. Method: Resveratrol-loaded ethosome was prepared using cold method. The prepared ethosomes were assessed for entrapment efficiency (%), TEM analysis and sedimentation rate to determine the optimal formulation for loading into cream base. The selected formulation was further investigated for particle size distribution and zeta potential. A cream base was formulated using fusion and trituration method and selected for loading with the ethosomal suspension, meeting specification suitable for topical delivery.  Ethosomal cream formulations were evaluated for drug content, ex -vitro diffusion by using goat skin, skin retention, microbiological study and stability study.  Result and Discussion: The formulation E3 was selected for loading in the optimized cream base (F4) to obtain a topical cream containing ethosomes of resveratrol. The release study reveals that release was controlled for the 24 hours. The drug release in buffer was less than 17% from all the formulations after 24 hours. The drug content of resveratrol in goat skin and cream remained in donor compartment indicates that the drug retention in skin was high in all the formulations, which is desirable for the topical formulations. The best possible release kinetics of the formulation loaded with resveratrol containing ethosomes was found to be zero order. The ‘n’ value from Peppas’s model indicated that the drug release was by Fickian diffusion. Stability study indicates that all the cream formulations were stable after a time period of one month. Conclusion: The present study conclusively supported that ethosomal cream containing resveratrol to be an advantageous topical drug delivery system in treatment of ACD. However detail in- vivo study should be conducted in future to be justify the in- vitro study. Keywords: Resveratrol, Ethosome, Cream, Contact dermatitis.
用于治疗接触性皮炎的含白藜芦醇的 Ethosomal 乳霜的配制与评估
研究目的本研究旨在配制和评估用于治疗接触性皮炎的含白藜芦醇的乙酰乳膏。方法:采用冷冻法制备白藜芦醇载体乙霜:采用冷冻法制备白藜芦醇载体。对制备的乙素体进行夹带效率(%)、TEM 分析和沉降率评估,以确定载入膏霜基质的最佳配方。对选定的配方进一步研究了粒度分布和 zeta 电位。使用熔融和滴定法配制了一种乳膏基质,并选择用于添加乙硫睾酮悬浮液,以满足适合局部给药的规格要求。 用山羊皮对乙硫嘧啶乳膏配方进行了药物含量、体外扩散、皮肤保留率、微生物研究和稳定性研究等方面的评估。 结果与讨论:在优化后的乳膏基质(F4)中加入配方 E3,得到了含有白藜芦醇乙硫体的外用乳膏。释放研究表明,24 小时内的释放是可控的。24 小时后,所有配方在缓冲液中的药物释放量都低于 17%。白藜芦醇在山羊皮和乳膏中的药物含量保持在供体区,这表明所有制剂在皮肤中的药物保留率都很高,这对于外用制剂来说是理想的。含有乙硫体的白藜芦醇制剂的最佳释放动力学为零阶。佩帕斯模型的 "n "值表明,药物释放是通过费克扩散作用进行的。稳定性研究表明,所有乳膏配方在一个月后均保持稳定。结论本研究证实,含有白藜芦醇的乙酰胆碱乳膏是治疗 ACD 的理想局部给药系统。不过,今后应进行详细的体内研究,以证明体外研究的正确性。关键词白藜芦醇 Ethosome 乳霜 接触性皮炎
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