{"title":"Nebulization versus injection in ambulatory treatment of acute asthma: a comparative study","authors":"Christer Janson, Merja Herala, Ingela Sjögren","doi":"10.1016/0007-0971(88)90087-3","DOIUrl":null,"url":null,"abstract":"<div><p>Nebulization treatment of acute asthma with terbutaline and ipratropium bromide, given either separately with a 30-minute interval or combined as single inhalation, was compared with injection treatment with a combination of terbutaline given subcutaneously and theophylline given intravenously.</p><p>Seventy-seven episodes of acute asthma were studied. Nebulization treatment gave the same degree of bronchodilation as the injections, both immediately after treatment [measured as increase in forced expiratory volume in 1 second (FEV<sub>1</sub>) in peak expiratory flow rate (PEFR) and improvement of dyspnoea] and during the following 6 days (measured by PEFR recordings at home).</p><p>The injection treatment caused a moderate increase in heart rate, whereas no circulatory side-effects were noted during nebulization treatment.</p><p>Administration of ipratropium bromide 30 minutes after terbutaline was not more effective than the combination of both substances as a single nebulization.</p></div>","PeriodicalId":75618,"journal":{"name":"British journal of diseases of the chest","volume":"82 ","pages":"Pages 347-353"},"PeriodicalIF":0.0000,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0007-0971(88)90087-3","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"British journal of diseases of the chest","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0007097188900873","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
Abstract
Nebulization treatment of acute asthma with terbutaline and ipratropium bromide, given either separately with a 30-minute interval or combined as single inhalation, was compared with injection treatment with a combination of terbutaline given subcutaneously and theophylline given intravenously.
Seventy-seven episodes of acute asthma were studied. Nebulization treatment gave the same degree of bronchodilation as the injections, both immediately after treatment [measured as increase in forced expiratory volume in 1 second (FEV1) in peak expiratory flow rate (PEFR) and improvement of dyspnoea] and during the following 6 days (measured by PEFR recordings at home).
The injection treatment caused a moderate increase in heart rate, whereas no circulatory side-effects were noted during nebulization treatment.
Administration of ipratropium bromide 30 minutes after terbutaline was not more effective than the combination of both substances as a single nebulization.
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