APPLICATION OF BOTULINUM TOXIN IN CONSERVATIVE TREATMENT OF MASTICATORY MUSCLES DYSFUNCTION

A. Mijoska, Sasho Jovanovski, B. Naumovski
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Abstract

The purpose of this paper is to describe the application of the botulinum toxin in diseases of the temporomandibular system of a muscular type such as masticatory hypertrophy, spasm, bruxism, and tension headaches of idiopathic etiology. The masticatory system is a complex apparatus with great adaptive capacity. Still, when that capacity is exceeded, functional disorders occur followed by a series of symptoms that depend on individual, local, and systemic etiological factors. Occlusal trauma exceeding the physiological limits of the teeth, periodontium, and TMJ leads to a series of functional disorders. Temporomandibular dysfunctions (TMD) are used to describe a large, heterogeneous group of diseases of the temporomandibular joint (TMJ) and its adjacent tissues and organs. Botulinum toxin type A, hemagglutinin complex with 500 IU (DISPORT Ipsen Biopharm, UK) was used for the therapy of muscle disorders like bruxism or night teeth clenching in female patient 26 years old. Depending on the dose that was applied to the targeted muscle, a complete or partial reduction in contraction occurs with reduced function and weakening of the muscle. Two weeks after applying the neuromodulator, the patient reported a reduction in pain and episodes of teeth grinding and clenching. Bilateral hypotrophy of left and right masseter muscles was noticeable after 2 months. We concluded that botulinum toxin could be used as an effective treatment for reducing nocturnal bruxism and myofascial pain in patients with bruxism.
肉毒杆菌毒素在咀嚼肌功能障碍保守治疗中的应用
本文旨在介绍肉毒杆菌毒素在颞下颌系统肌肉型疾病中的应用,如咀嚼肥大、痉挛、磨牙症和特发性紧张性头痛。咀嚼系统是一个复杂的装置,具有很强的适应能力。然而,当超过这种能力时,就会出现功能障碍,继而出现一系列症状,这些症状取决于个体、局部和全身的病因因素。咬合创伤超过了牙齿、牙周和颞下颌关节的生理极限,就会导致一系列功能紊乱。颞下颌功能障碍(TMD)用于描述颞下颌关节(TMJ)及其邻近组织和器官的一大类异质性疾病。A 型肉毒杆菌毒素血凝素复合物 500 IU(DISPORT Ipsen Biopharm,英国)用于治疗 26 岁女性患者的磨牙症或夜间牙齿紧咬等肌肉疾病。根据施用在目标肌肉上的剂量,肌肉收缩会完全或部分减弱,肌肉功能降低,肌肉变弱。使用神经调节剂两周后,患者报告疼痛减轻,磨牙和咬牙发作减少。两个月后,双侧左右咀嚼肌明显萎缩。我们的结论是,肉毒杆菌毒素可作为一种有效的治疗方法,用于减少磨牙症患者的夜间磨牙症和肌筋膜疼痛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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